RABEPK

Protein-coding gene in the species Homo sapiens
RABEPK
Identifiers
AliasesRABEPK, RAB9P40, bA65N13.1, p40, Rab9 effector protein with kelch motifs
External IDsOMIM: 605962; MGI: 2139530; HomoloGene: 48772; GeneCards: RABEPK; OMA:RABEPK - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RABEPK
Genomic location for RABEPK
Band9q33.3Start125,200,542 bp[1]
End125,234,161 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RABEPK
Genomic location for RABEPK
Band2|2 BStart34,667,568 bp[2]
End34,689,924 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • buccal mucosa cell

  • nucleus accumbens

  • putamen

  • caudate nucleus

  • prefrontal cortex

  • stromal cell of endometrium

  • right frontal lobe

  • Brodmann area 9

  • cingulate gyrus
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • yolk sac

  • dentate gyrus of hippocampal formation granule cell

  • embryo

  • epiblast

  • embryo

  • blastocyst

  • right kidney
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10244

227746

Ensembl

ENSG00000136933

ENSMUSG00000070953

UniProt

Q7Z6M1
Q5T1S5

Q8VCH5

RefSeq (mRNA)

NM_001174152
NM_001174153
NM_005833

NM_145522
NM_001374669

RefSeq (protein)

NP_001167623
NP_001167624
NP_005824

NP_663497
NP_001361598

Location (UCSC)Chr 9: 125.2 – 125.23 MbChr 2: 34.67 – 34.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.[5][6]

Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.[5]

Interactions

RABEPK has been shown to interact with RAB9A[5] and FYVE finger-containing phosphoinositide kinase.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136933 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070953 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Diaz E, Schimmoller F, Pfeffer SR (Aug 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
  6. ^ "Entrez Gene: RABEPK Rab9 effector protein with kelch motifs".
  7. ^ Ikonomov, Ognian C; Sbrissa Diego; Mlak Krzysztof; Deeb Robert; Fligger Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. ISSN 0021-9258. PMID 14530284.

Further reading

  • Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMC 2063917. PMID 16769818.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
  • Ikonomov OC, Sbrissa D, Mlak K, et al. (2004). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. PMID 14530284.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • v
  • t
  • e