Protein-coding gene in the species Homo sapiens
RABEPK |
---|
|
Identifiers |
---|
Aliases | RABEPK, RAB9P40, bA65N13.1, p40, Rab9 effector protein with kelch motifs |
---|
External IDs | OMIM: 605962; MGI: 2139530; HomoloGene: 48772; GeneCards: RABEPK; OMA:RABEPK - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 9 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Ideogram_human_chromosome_9.svg/300px-Ideogram_human_chromosome_9.svg.png) | Chr. | Chromosome 9 (human)[1] |
---|
| Band | 9q33.3 | Start | 125,200,542 bp[1] |
---|
End | 125,234,161 bp[1] |
---|
|
Gene location (Mouse) |
---|
![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
---|
| Band | 2|2 B | Start | 34,667,568 bp[2] |
---|
End | 34,689,924 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - right lobe of liver
- buccal mucosa cell
- nucleus accumbens
- putamen
- caudate nucleus
- prefrontal cortex
- stromal cell of endometrium
- right frontal lobe
- Brodmann area 9
- cingulate gyrus
|
| Top expressed in | - spermatid
- seminiferous tubule
- spermatocyte
- yolk sac
- dentate gyrus of hippocampal formation granule cell
- embryo
- epiblast
- embryo
- blastocyst
- right kidney
|
| More reference expression data |
|
---|
BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/PBB_GE_RABEPK_203150_at_fs.png/250px-PBB_GE_RABEPK_203150_at_fs.png) | More reference expression data |
|
---|
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001174152 NM_001174153 NM_005833 |
| |
---|
RefSeq (protein) | |
---|
NP_001167623 NP_001167624 NP_005824 |
| |
---|
Location (UCSC) | Chr 9: 125.2 – 125.23 Mb | Chr 2: 34.67 – 34.69 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.[5][6]
Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.[5]
Interactions
RABEPK has been shown to interact with RAB9A[5] and FYVE finger-containing phosphoinositide kinase.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136933 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070953 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Diaz E, Schimmoller F, Pfeffer SR (Aug 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
- ^ "Entrez Gene: RABEPK Rab9 effector protein with kelch motifs".
- ^ Ikonomov, Ognian C; Sbrissa Diego; Mlak Krzysztof; Deeb Robert; Fligger Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. ISSN 0021-9258. PMID 14530284.
Further reading
- Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMC 2063917. PMID 16769818.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
- Ikonomov OC, Sbrissa D, Mlak K, et al. (2004). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. PMID 14530284.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links