RECQL5

Protein-coding gene in the species Homo sapiens
RECQL5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4BK0, 5LB8, 5LB5, 5LBA, 5LB3

Identifiers
AliasesRECQL5, RECQ5, RecQ like helicase 5
External IDsOMIM: 603781; MGI: 2156841; HomoloGene: 31232; GeneCards: RECQL5; OMA:RECQL5 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RECQL5
Genomic location for RECQL5
Band17q25.1Start75,626,845 bp[1]
End75,667,189 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RECQL5
Genomic location for RECQL5
Band11|11 E2Start115,783,421 bp[2]
End115,824,303 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • right uterine tube

  • left lobe of thyroid gland

  • left testis

  • anterior pituitary

  • right testis

  • sural nerve

  • skin of abdomen

  • body of stomach

  • skin of leg
Top expressed in
  • granulocyte

  • zygote

  • spermatid

  • neural layer of retina

  • secondary oocyte

  • lip

  • tail of embryo

  • corneal stroma

  • ventricular zone

  • plantaris muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II complex binding
  • nucleotide binding
  • helicase activity
  • DNA helicase activity
  • nucleic acid binding
  • hydrolase activity
  • ATP binding
  • DNA binding
  • 3'-5' DNA helicase activity
  • four-way junction helicase activity
  • protein binding
  • identical protein binding
Cellular component
  • RNA polymerase II, holoenzyme
  • nucleoplasm
  • nucleus
  • chromosome
  • cytoplasm
  • cytosol
Biological process
  • DNA recombination
  • DNA metabolic process
  • negative regulation of transcription elongation from RNA polymerase II promoter
  • cellular response to DNA damage stimulus
  • cell division
  • chromosome separation
  • DNA replication
  • cell cycle
  • DNA repair
  • DNA duplex unwinding
  • double-strand break repair via homologous recombination
  • cellular response to camptothecin
  • replication-born double-strand break repair via sister chromatid exchange
  • negative regulation of double-strand break repair via homologous recombination
  • mitotic cell cycle
  • mitotic sister chromatid segregation
  • response to X-ray
  • negative regulation of mitotic cell cycle
  • DNA unwinding involved in DNA replication
  • metabolism
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9400

170472

Ensembl

ENSG00000108469

ENSMUSG00000020752

UniProt

O94762

Q8VID5

RefSeq (mRNA)

NM_001003715
NM_001003716
NM_004259

NM_130454

RefSeq (protein)

NP_001003715
NP_001003716
NP_004250

NP_569721

Location (UCSC)Chr 17: 75.63 – 75.67 MbChr 11: 115.78 – 115.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.[5][6]

Interactions

RECQL5 has been shown to interact with EEF1G.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108469 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020752 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
  6. ^ "Entrez Gene: RECQL5 RecQ protein-like 5".
  7. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Further reading

  • Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (Sep 1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing". Nucleic Acids Research. 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633. PMID 10471747.
  • Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (Apr 2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Research. 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432.
  • Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (Jul 2004). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide". The EMBO Journal. 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958. PMID 15241474.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (May 2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers". Molecular and Cellular Biology. 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310. PMID 15831450.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork". Nucleic Acids Research. 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296. PMID 17003056.
  • Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments". Genes & Development. 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974. PMID 18003859.


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