SEMA3C

Protein-coding gene in the species Homo sapiens
SEMA3C
Identifiers
AliasesSEMA3C, SEMAE, SemE, semaphorin 3C
External IDsOMIM: 602645; MGI: 107557; HomoloGene: 36201; GeneCards: SEMA3C; OMA:SEMA3C - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SEMA3C
Genomic location for SEMA3C
Band7q21.11Start80,742,538 bp[1]
End80,922,359 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SEMA3C
Genomic location for SEMA3C
Band5|5 A3Start17,779,279 bp[2]
End17,935,266 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lactiferous duct

  • synovial joint

  • Achilles tendon

  • cartilage tissue

  • germinal epithelium

  • skin of hip

  • vena cava

  • synovial membrane

  • tail of epididymis

  • biceps brachii
Top expressed in
  • retinal pigment epithelium

  • right lung lobe

  • submandibular gland

  • ankle

  • medullary collecting duct

  • left colon

  • calvaria

  • skin of external ear

  • vas deferens

  • seminal vesicula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • semaphorin receptor binding
  • neuropilin binding
  • chemorepellent activity
Cellular component
  • extracellular region
  • extracellular exosome
  • extracellular space
  • integral component of plasma membrane
Biological process
  • somitogenesis
  • cell differentiation
  • limb bud formation
  • outflow tract morphogenesis
  • post-embryonic development
  • nervous system development
  • axon guidance
  • multicellular organism development
  • heart development
  • blood vessel remodeling
  • pulmonary myocardium development
  • immune response
  • neural tube development
  • dichotomous subdivision of terminal units involved in salivary gland branching
  • cardiac right ventricle morphogenesis
  • neural crest cell migration
  • negative chemotaxis
  • outflow tract septum morphogenesis
  • semaphorin-plexin signaling pathway
  • cardiac endothelial to mesenchymal transition
  • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
  • positive regulation of cell migration
  • negative regulation of axon extension involved in axon guidance
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10512

20348

Ensembl

ENSG00000075223

ENSMUSG00000028780

UniProt

Q99985

Q62181

RefSeq (mRNA)

NM_006379
NM_001350120
NM_001350121

NM_013657

RefSeq (protein)

NP_006370
NP_001337049
NP_001337050

NP_038685

Location (UCSC)Chr 7: 80.74 – 80.92 MbChr 5: 17.78 – 17.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075223 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028780 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  6. ^ Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980.
  7. ^ "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
  • Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. Bibcode:1997PNAS...9414713Y. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
  • Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914.
  • Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958. S2CID 45643250.
  • Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297.
  • Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325. S2CID 39883399.
  • Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.
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