SEPT11

Protein-coding gene in the species Homo sapiens

SEPTIN11
Identifiers
AliasesSEPTIN11, septin 11, SEPT11
External IDsOMIM: 612887; MGI: 1277214; HomoloGene: 56800; GeneCards: SEPTIN11; OMA:SEPTIN11 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SEPTIN11
Genomic location for SEPTIN11
Band4q21.1Start76,949,751 bp[1]
End77,040,384 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SEPTIN11
Genomic location for SEPTIN11
Band5 E2|5 47.29 cMStart93,241,296 bp[2]
End93,324,306 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • Achilles tendon

  • stromal cell of endometrium

  • sural nerve

  • epithelium of colon

  • periodontal fiber

  • decidua

  • Brodmann area 9

  • right frontal lobe
Top expressed in
  • Gonadal ridge

  • maxillary prominence

  • mandibular prominence

  • dermis

  • tail of embryo

  • abdominal wall

  • ventricular zone

  • genital tubercle

  • renal corpuscle

  • atrioventricular valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
  • molecular adaptor activity
Cellular component
  • cytoplasm
  • axon
  • cell junction
  • dendritic spine
  • cell projection
  • synapse
  • cytoskeleton
  • stress fiber
  • postsynapse
  • glutamatergic synapse
  • GABA-ergic synapse
  • postsynaptic specialization of symmetric synapse
  • septin ring
  • microtubule cytoskeleton
  • septin complex
  • septin filament array
Biological process
  • cell cycle
  • protein heterooligomerization
  • cell division
  • regulation of synapse organization
  • mitotic cytokinesis
  • septin ring assembly
  • cilium assembly
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55752

52398

Ensembl

ENSG00000138758

ENSMUSG00000058013

UniProt

Q9NVA2

Q8C1B7

RefSeq (mRNA)

NM_001306147
NM_018243

NM_001009818
NM_001310669
NM_001310671
NM_001347377

RefSeq (protein)

NP_001293076
NP_060713

NP_001009818
NP_001297598
NP_001297600
NP_001334306

Location (UCSC)Chr 4: 76.95 – 77.04 MbChr 5: 93.24 – 93.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-11 is a protein that in humans is encoded by the SEPT11 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138758 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058013 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kojima K, Sakai I, Hasegawa A, Niiya H, Azuma T, Matsuo Y, Fujii N, Tanimoto M, Fujita S (May 2004). "FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)". Leukemia. 18 (5): 998–1005. doi:10.1038/sj.leu.2403334. PMID 14999297. S2CID 7182039.
  6. ^ Kim DS, Hubbard SL, Peraud A, Salhia B, Sakai K, Rutka JT (May 2004). "Analysis of mammalian septin expression in human malignant brain tumors". Neoplasia. 6 (2): 168–78. doi:10.1593/neo.03310. PMC 1502092. PMID 15140406.
  7. ^ "Entrez Gene: SEPT11 septin 11".

Further reading

  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Hanai N, Nagata K, Kawajiri A, Shiromizu T, Saitoh N, Hasegawa Y, Murakami S, Inagaki M (June 2004). "Biochemical and cell biological characterization of a mammalian septin, Sept11". FEBS Letters. 568 (1–3): 83–8. doi:10.1016/j.febslet.2004.05.030. PMID 15196925. S2CID 11315113.
  • Nagata K, Asano T, Nozawa Y, Inagaki M (December 2004). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11". The Journal of Biological Chemistry. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (October 2007). "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling". Human Mutation. 28 (10): 1005–13. doi:10.1002/humu.20554. PMID 17546647. S2CID 40174453.
  • Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (November 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527. PMID 17625225.


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