Protein-coding gene in the species Homo sapiens
| SOCS4 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | SOCS4, SOCS7, suppressor of cytokine signaling 4 |
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| External IDs | OMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 14 (human)[1] |
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| | Band | 14q22.3 | Start | 55,027,230 bp[1] |
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| End | 55,049,489 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 14 (mouse)[2] |
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| | Band | 14|14 C1 | Start | 47,514,388 bp[2] |
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| End | 47,533,559 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - pancreatic epithelial cell
- tibia
- visceral pleura
- parietal pleura
- tail of epididymis
- germinal epithelium
- mucosa of ileum
- mucosa of paranasal sinus
- cardiac muscle tissue of right atrium
- tibialis anterior muscle
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| | Top expressed in | - medial ganglionic eminence
- conjunctival fornix
- vestibular membrane of cochlear duct
- epithelium of small intestine
- carotid body
- atrioventricular valve
- lymph node
- trigeminal ganglion
- lumbar spinal ganglion
- hair follicle
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - protein kinase inhibitor activity
- protein binding
| | Cellular component | - cytoplasm
- intracellular anatomical structure
| | Biological process | - negative regulation of epidermal growth factor-activated receptor activity
- regulation of growth
- negative regulation of signal transduction
- intracellular signal transduction
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- cytokine-mediated signaling pathway
- negative regulation of receptor signaling pathway via JAK-STAT
| | Sources:Amigo / QuickGO |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.[5]
Function
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)
