SPRR2A

Protein-coding gene in the species Homo sapiens

SPRR2A
Identifiers
AliasesSPRR2A, small proline rich protein 2A
External IDsOMIM: 182267; MGI: 1330343; HomoloGene: 130544; GeneCards: SPRR2A; OMA:SPRR2A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SPRR2A
Genomic location for SPRR2A
Band1q21.3Start153,056,120 bp[1]
End153,057,512 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SPRR2A
Genomic location for SPRR2A
Band3 F1|3 40.14 cMStart92,292,992 bp[2]
End92,294,631 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • gums

  • gingival epithelium

  • body of tongue

  • amniotic fluid

  • mucosa of pharynx

  • oral cavity

  • human penis

  • nasal epithelium

  • vulva
Top expressed in
  • gastrula

  • decidua

  • cervix

  • skin of back

  • lip

  • skin of abdomen

  • skin of external ear

  • belly cord

  • sexually immature organism

  • esophagus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • structural molecule activity
Cellular component
  • cytoplasm
  • cornified envelope
  • cytosol
Biological process
  • peptide cross-linking
  • keratinization
  • keratinocyte differentiation
  • epidermis development
  • cornification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6700

20762

Ensembl

ENSG00000241794

ENSMUSG00000046259

UniProt

P35326

O70559

RefSeq (mRNA)

NM_005988

NM_011474

RefSeq (protein)

NP_005979

NP_035604

Location (UCSC)Chr 1: 153.06 – 153.06 MbChr 3: 92.29 – 92.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241794 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046259 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
  6. ^ "Entrez Gene: SPRR2A small proline-rich protein 2A".

Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Tong L, Corrales RM, Chen Z, et al. (2006). "Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium". Invest. Ophthalmol. Vis. Sci. 47 (5): 1938–46. doi:10.1167/iovs.05-1129. PMC 2906387. PMID 16639001.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus". Mol. Cells. 17 (3): 477–84. doi:10.1016/S1016-8478(23)13069-X. PMID 15232223.
  • Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Fischer DF, van Drunen CM, Winkler GS, et al. (1999). "Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker". Nucleic Acids Res. 26 (23): 5288–94. doi:10.1093/nar/26.23.5288. PMC 147987. PMID 9826750.
  • Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
  • Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996). "Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation". Mol. Cell. Biol. 16 (10): 5365–74. doi:10.1128/MCB.16.10.5365. PMC 231535. PMID 8816448.
  • Gibbs S, Lohman F, Teubel W, et al. (1990). "Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes". Nucleic Acids Res. 18 (15): 4401–7. doi:10.1093/nar/18.15.4401. PMC 331257. PMID 2388825.


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