SYT4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/33/Protein_SYT4_PDB_1ugk.png/250px-Protein_SYT4_PDB_1ugk.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | SYT4, HsT1192, synaptotagmin 4 |
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External IDs | OMIM: 600103; MGI: 101759; HomoloGene: 7559; GeneCards: SYT4; OMA:SYT4 - orthologs |
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Gene location (Human) |
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![Chromosome 18 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_human_chromosome_18.svg/300px-Ideogram_human_chromosome_18.svg.png) | Chr. | Chromosome 18 (human)[1] |
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| Band | 18q12.3 | Start | 43,267,892 bp[1] |
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End | 43,277,535 bp[1] |
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Gene location (Mouse) |
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![Chromosome 18 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png) | Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18 B1|18 17.75 cM | Start | 31,570,861 bp[2] |
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End | 31,580,459 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - cerebellar vermis
- endothelial cell
- cerebellar hemisphere
- Brodmann area 23
- right hemisphere of cerebellum
- Brodmann area 46
- middle temporal gyrus
- superior frontal gyrus
- superior vestibular nucleus
- islet of Langerhans
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| Top expressed in | - lobe of cerebellum
- cerebellar vermis
- ventral tegmental area
- pineal gland
- dorsomedial hypothalamic nucleus
- habenula
- anterior amygdaloid area
- ventromedial nucleus
- paraventricular nucleus of hypothalamus
- lateral hypothalamus
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/7/76/PBB_GE_SYT4_gnf1h05705_at_fs.png/250px-PBB_GE_SYT4_gnf1h05705_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PBB_GE_SYT4_gnf1h05706_at_fs.png/250px-PBB_GE_SYT4_gnf1h05706_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - calcium ion binding
- clathrin binding
- phosphatidylserine binding
- metal ion binding
- protein binding
- SNARE binding
- syntaxin-1 binding
- syntaxin binding
- syntaxin-3 binding
- protein homodimerization activity
- protein heterodimerization activity
- calcium-dependent phospholipid binding
| Cellular component | - integral component of membrane
- intracellular membrane-bounded organelle
- membrane
- synapse
- synaptic vesicle membrane
- cell junction
- perinuclear region of cytoplasm
- neuron projection
- dense core granule
- cytoplasmic vesicle
- dendrite
- Golgi apparatus
- vesicle
- axon
- plasma membrane
- synaptic vesicle
- integral component of Golgi membrane
- integral component of synaptic vesicle membrane
- secretory granule membrane
- dense core granule membrane
- somatodendritic compartment
- neuronal cell body
- neuron projection terminus
- exocytic vesicle
- astrocyte projection
- microvesicle
- glutamatergic synapse
- integral component of neuronal dense core vesicle membrane
| Biological process | - cell differentiation
- brain development
- positive regulation of dendrite extension
- negative regulation of vesicle fusion
- neurotransmitter secretion
- exocytosis
- vesicle fusion
- calcium ion-regulated exocytosis of neurotransmitter
- memory
- positive regulation of glutamate secretion
- regulation of dopamine secretion
- regulation of endocytosis
- regulation of vesicle fusion
- negative regulation of catecholamine secretion
- positive regulation of calcium ion-dependent exocytosis
- negative regulation of neurotransmitter secretion
- negative regulation of short-term neuronal synaptic plasticity
- vesicle fusion with vesicle
- secretory granule maturation
- negative regulation of protein secretion
- negative regulation of retrograde trans-synaptic signaling by neuropeptide
- regulation of calcium ion-dependent exocytosis
- negative regulation of calcium ion-dependent exocytosis
- trans-synaptic signaling by BDNF, modulating synaptic transmission
- vesicle-mediated transport
- calcium-ion regulated exocytosis
- cellular response to calcium ion
- regulation of presynaptic dense core granule exocytosis
- negative regulation of dense core granule exocytosis
- positive regulation of dense core granule exocytosis
- negative regulation of synaptic vesicle exocytosis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 18: 43.27 – 43.28 Mb | Chr 18: 31.57 – 31.58 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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