TDRKH

Protein-coding gene in the species Homo sapiens
TDRKH
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DIQ, 3FDR, 5J39

Identifiers
AliasesTDRKH, TDRD2, tudor and KH domain containing
External IDsOMIM: 609501; MGI: 1919884; HomoloGene: 4999; GeneCards: TDRKH; OMA:TDRKH - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TDRKH
Genomic location for TDRKH
Band1q21.3Start151,770,107 bp[1]
End151,791,416 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for TDRKH
Genomic location for TDRKH
Band3|3 F2.1Start94,320,580 bp[2]
End94,341,975 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • right testis

  • left testis

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • testicle

  • prefrontal cortex

  • ganglionic eminence

  • secondary oocyte

  • right frontal lobe
Top expressed in
  • neural layer of retina

  • zygote

  • ventricular zone

  • primary oocyte

  • lens

  • secondary oocyte

  • dentate gyrus of hippocampal formation granule cell

  • neural tube

  • ganglionic eminence

  • otolith organ
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • RNA binding
  • nucleic acid binding
Cellular component
  • cytoplasm
  • pi-body
  • mitochondrion
  • piP-body
Biological process
  • male meiotic nuclear division
  • fertilization
  • cell differentiation
  • DNA methylation involved in gamete generation
  • spermatogenesis
  • gene silencing
  • piRNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11022

72634

Ensembl

ENSG00000182134

ENSMUSG00000041912

UniProt

Q9Y2W6

Q80VL1

RefSeq (mRNA)

NM_001083963
NM_001083964
NM_001083965
NM_006862

NM_028307
NM_001357711
NM_001357712
NM_001357713
NM_001357714

RefSeq (protein)

NP_001077432
NP_001077433
NP_001077434
NP_006853

NP_082583
NP_001344640
NP_001344641
NP_001344642
NP_001344643

Location (UCSC)Chr 1: 151.77 – 151.79 MbChr 3: 94.32 – 94.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tudor and KH domain-containing protein is a protein that in humans is encoded by the TDRKH gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182134 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041912 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lamb FS, Barna TJ, Goud C, Marenholz I, Mischke D, Schutte BC (May 2000). "Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains". Gene. 246 (1–2): 209–18. doi:10.1016/S0378-1119(00)00087-1. PMID 10767542.
  6. ^ "Entrez Gene: TDRKH tudor and KH domain containing".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Côté J, Richard S (2005). "Tudor domains bind symmetrical dimethylated arginines". J. Biol. Chem. 280 (31): 28476–83. doi:10.1074/jbc.M414328200. PMID 15955813.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • v
  • t
  • e
  • 1we8: Solution structure of KH domain in protein BAB28342
    1we8: Solution structure of KH domain in protein BAB28342
  • 2diq: Solution structure of the TUDOR domain of Tudor and KH domain containing protein
    2diq: Solution structure of the TUDOR domain of Tudor and KH domain containing protein


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