TINAGL1

Protein-coding gene in the species Homo sapiens
TINAGL1
Identifiers
AliasesTINAGL1, ARG1, LCN7, LIECG3, TINAGRP, tubulointerstitial nephritis antigen like 1
External IDsOMIM: 616064; MGI: 2137617; HomoloGene: 41472; GeneCards: TINAGL1; OMA:TINAGL1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TINAGL1
Genomic location for TINAGL1
Band1p35.2Start31,576,485 bp[1]
End31,587,686 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TINAGL1
Genomic location for TINAGL1
Band4|4 D2.2Start130,058,247 bp[2]
End130,068,915 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • ascending aorta

  • popliteal artery

  • tibial arteries

  • Descending thoracic aorta

  • apex of heart

  • left coronary artery

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • left uterine tube
Top expressed in
  • granulocyte

  • ascending aorta

  • decidua

  • yolk sac

  • external carotid artery

  • belly cord

  • endothelial cell of lymphatic vessel

  • pyloric antrum

  • aortic valve

  • tunica media of zone of aorta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • scavenger receptor activity
  • polysaccharide binding
  • cysteine-type endopeptidase activity
  • laminin binding
  • extracellular matrix structural constituent
  • protein binding
  • cysteine-type peptidase activity
Cellular component
  • cytoplasm
  • extracellular matrix
  • extracellular region
  • lysosome
  • extracellular exosome
  • extracellular space
  • collagen-containing extracellular matrix
Biological process
  • endosomal transport
  • cell adhesion
  • proteolysis involved in cellular protein catabolic process
  • receptor-mediated endocytosis
  • immune response
  • proteolysis
  • endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64129

94242

Ensembl

ENSG00000142910

ENSMUSG00000028776

UniProt

Q9GZM7

Q99JR5

RefSeq (mRNA)

NM_001204414
NM_001204415
NM_022164

NM_001168333
NM_023476

RefSeq (protein)

NP_001191343
NP_001191344
NP_071447

NP_001161805
NP_075965

Location (UCSC)Chr 1: 31.58 – 31.59 MbChr 4: 130.06 – 130.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142910 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028776 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wex T, Lipyansky A, Bromme NC, Wex H, Guan XQ, Bromme D (Feb 2001). "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells". Biochemistry. 40 (5): 1350–7. doi:10.1021/bi002266o. PMID 11170462.
  6. ^ "Entrez Gene: TINAGL1 tubulointerstitial nephritis antigen-like 1".

Further reading

  • Brömme NC, Wex T, Wex H, et al. (2000). "Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein". Biochem. Biophys. Res. Commun. 271 (2): 474–80. doi:10.1006/bbrc.2000.2639. PMID 10799322.
  • Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Umeyama H, Iwadate M, Taguchi YH (2014). "TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer". BMC Genomics. 15 (Suppl 9): S2. doi:10.1186/1471-2164-15-S9-S2. PMC 4290609. PMID 25521548.
  • Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A (2016). "Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines". Proteomics. 16 (21): 2801–2814. doi:10.1002/pmic.201600297. PMID 27569058. S2CID 38155519.


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