TOMM20

Protein-coding gene in the species Homo sapiens

TOMM20

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4APO

Identifiers

Aliases

TOMM20, MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20

External IDs

OMIM: 601848; MGI: 1915202; HomoloGene: 44649; GeneCards: TOMM20; OMA:TOMM20 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q42.3	Start	235,109,341 bp^[1]
Band	1q42.3	End	235,128,837 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E2	Start	127,657,417 bp^[2]
Band	8\|8 E2	End	127,672,594 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

skin of thigh

Brodmann area 10

frontal pole

skin of hip

middle frontal gyrus

caput epididymis

lateral nuclear group of thalamus

corpus epididymis

pons

Top expressed in

yolk sac

embryo

embryo

olfactory tubercle

nucleus accumbens

superior frontal gyrus

subiculum

ventromedial nucleus

temporal lobe

dentate gyrus of hippocampal formation granule cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein-transporting ATPase activity protein binding mitochondrion targeting sequence binding unfolded protein binding protein transmembrane transporter activity
Cellular component	integral component of membrane mitochondria-associated endoplasmic reticulum membrane membrane mitochondrial outer membrane translocase complex integral component of mitochondrial outer membrane mitochondrial outer membrane mitochondrion mitochondrial envelope
Biological process	protein targeting tRNA import into mitochondrion mitochondrial outer membrane translocase complex assembly protein import into mitochondrial matrix protein transport intracellular protein transport protein targeting to mitochondrion protein deubiquitination response to muscle activity response to 3,3',5-triiodo-L-thyronine macroautophagy
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9804


67952

Ensembl


ENSG00000173726


ENSMUSG00000093904

UniProt


Q15388


Q9DCC8

RefSeq (mRNA)


NM_014765


NM_024214

RefSeq (protein)


NP_055580 NP_055580.1


NP_077176

Location (UCSC)

Chr 1: 235.11 – 235.13 Mb

Chr 8: 127.66 – 127.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.^[5]^[6]^[7]^[8] TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

Function

In mitochondrial protein import, TOM20 is closely associated with the pore-forming TOM40 complex and acts by recognizing and binding the N-terminal MTSs (matrix-targeting sequences), which form an amphipathic alpha helix and aid passage of the target proteins into the mitochondrial matrix.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173726 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000093904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, et al. (November 1995). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Letters. 375 (3): 307–310. doi:10.1016/0014-5793(95)01229-8. PMID 7498524. S2CID 45148104.
^ Goping IS, Millar DG, Shore GC (October 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Letters. 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID 7589431. S2CID 1204415.
^ Likić VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, et al. (March 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". Journal of Molecular Biology. 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID 15733919.
^ "Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".
^ Hansen KG, Herrmann JM (June 2019). "Transport of Proteins into Mitochondria". The Protein Journal. 38 (3): 330–342. doi:10.1007/s10930-019-09819-6. PMID 30868341. S2CID 76662487.

Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Research. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Schleiff E, Shore GC, Goping IS (March 1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins". FEBS Letters. 404 (2–3): 314–318. doi:10.1016/S0014-5793(97)00145-2. PMID 9119086. S2CID 29177508.
Schleiff E, Shore GC, Goping IS (July 1997). "Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements". The Journal of Biological Chemistry. 272 (28): 17784–17789. doi:10.1074/jbc.272.28.17784. PMID 9211931.
Schleiff E, Turnbull JL (September 1998). "Characterization of the N-terminal targeting signal binding domain of the mitochondrial outer membrane receptor, Tom20". Biochemistry. 37 (38): 13052–13058. doi:10.1021/bi980746y. PMID 9748310.
Yano M, Kanazawa M, Terada K, Takeya M, Hoogenraad N, Mori M (October 1998). "Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria". The Journal of Biological Chemistry. 273 (41): 26844–26851. doi:10.1074/jbc.273.41.26844. PMID 9756929.
Hernández JM, Giner P, Hernández-Yago J (November 1999). "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes". Gene. 239 (2): 283–291. doi:10.1016/S0378-1119(99)00409-6. PMID 10548729.
Suzuki H, Okazawa Y, Komiya T, Saeki K, Mekada E, Kitada S, et al. (December 2000). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". The Journal of Biological Chemistry. 275 (48): 37930–37936. doi:10.1074/jbc.M006558200. PMID 10980201.
Yano M, Hoogenraad N, Terada K, Mori M (October 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Molecular and Cellular Biology. 20 (19): 7205–7213. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
Abdul KM, Terada K, Yano M, Ryan MT, Streimann I, Hoogenraad NJ, Mori M (October 2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex". Biochemical and Biophysical Research Communications. 276 (3): 1028–1034. CiteSeerX 10.1.1.379.8183. doi:10.1006/bbrc.2000.3589. PMID 11027586.
Mukhopadhyay A, Avramova LV, Weiner H (April 2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Archives of Biochemistry and Biophysics. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Yano M, Terada K, Mori M (October 2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". The Journal of Cell Biology. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
Yano M, Terada K, Mori M (March 2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". The Journal of Biological Chemistry. 279 (11): 10808–10813. doi:10.1074/jbc.M311710200. PMID 14699115.
Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT (March 2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". The Journal of Biological Chemistry. 280 (12): 11535–11543. doi:10.1074/jbc.M413816200. PMID 15644312.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

PDB gallery

1om2: SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)