TRIM9

Protein-coding gene in the species Homo sapiens
TRIM9
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DB8

Identifiers
AliasesTRIM9, RNF91, SPRING, tripartite motif containing 9
External IDsOMIM: 606555; MGI: 2137354; HomoloGene: 9045; GeneCards: TRIM9; OMA:TRIM9 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for TRIM9
Genomic location for TRIM9
Band14q22.1Start50,975,262 bp[1]
End51,096,061 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TRIM9
Genomic location for TRIM9
Band12|12 C2Start70,291,307 bp[2]
End70,394,388 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • Brodmann area 23

  • primary visual cortex

  • Brodmann area 9

  • Region I of hippocampus proper

  • middle temporal gyrus

  • ventricular zone

  • nucleus accumbens

  • caudate nucleus
Top expressed in
  • piriform cortex

  • lateral septal nucleus

  • Rostral migratory stream

  • primary motor cortex

  • superior frontal gyrus

  • subiculum

  • primary visual cortex

  • anterior amygdaloid area

  • olfactory tubercle

  • medial dorsal nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • zinc ion binding
  • protein binding
  • protein homodimerization activity
  • transferase activity
  • protein domain specific binding
  • ubiquitin-protein transferase activity
  • SNARE binding
Cellular component
  • cytoplasm
  • cytoplasmic vesicle
  • cell junction
  • dendrite
  • cell projection
  • synapse
  • cytoskeleton
  • synaptic vesicle
  • intracellular anatomical structure
  • cytosol
  • presynaptic cytosol
Biological process
  • negative regulation of calcium ion-dependent exocytosis
  • protein ubiquitination
  • negative regulation of SNARE complex assembly
  • synaptic vesicle exocytosis
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114088

94090

Ensembl

ENSG00000100505

ENSMUSG00000021071

UniProt

Q9C026

Q8C7M3

RefSeq (mRNA)

NM_015163
NM_052978

NM_001110202
NM_001110203
NM_001286386
NM_001286387
NM_001286388

NM_053167

RefSeq (protein)

NP_055978
NP_443210

NP_001103672
NP_001103673
NP_001273315
NP_001273316
NP_001273317

NP_444397
NP_001392290
NP_001392291
NP_001392292
NP_001392293
NP_001392294
NP_001392295
NP_001392296
NP_001392297
NP_001392298
NP_001392299
NP_001392300
NP_001392301
NP_001392302
NP_001392303
NP_001392304
NP_001392305
NP_001392306
NP_001392307
NP_001392308
NP_001392309
NP_001392310
NP_001392311
NP_001392312
NP_001392313
NP_001392314
NP_001392315
NP_001392316

Location (UCSC)Chr 14: 50.98 – 51.1 MbChr 12: 70.29 – 70.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.[5][6][7]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.[7]

Interactions

TRIM9 has been shown to interact with SNAP-25.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100505 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021071 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. ^ a b Li Y, Chin LS, Weigel C, Li L (Oct 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". J Biol Chem. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
  7. ^ a b "Entrez Gene: TRIM9 tripartite motif-containing 9".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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  • 2db8: Solution structures of the fn3 domain of human Tripartite motif protein 9
    2db8: Solution structures of the fn3 domain of human Tripartite motif protein 9


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