TSPYL2

Protein-coding gene in humans
TSPYL2
Identifiers
AliasesTSPYL2, CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX, TSPY-like 2, TSPY like 2
External IDsOMIM: 300564; MGI: 106244; HomoloGene: 11140; GeneCards: TSPYL2; OMA:TSPYL2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for TSPYL2
Genomic location for TSPYL2
BandXp11.22Start53,082,367 bp[1]
End53,088,540 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for TSPYL2
Genomic location for TSPYL2
BandX F3|X 68.46 cMStart151,119,848 bp[2]
End151,125,421 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • right hemisphere of cerebellum

  • left ovary

  • right ovary

  • right frontal lobe

  • right testis

  • left testis

  • gastric mucosa

  • tibial nerve

  • left uterine tube
Top expressed in
  • neural layer of retina

  • dorsomedial hypothalamic nucleus

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • paraventricular nucleus of hypothalamus

  • ventromedial nucleus

  • genital tubercle

  • arcuate nucleus

  • cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • rDNA binding
  • protein binding
Cellular component
  • nucleolus
  • nucleoplasm
  • nucleus
  • cytoplasm
Biological process
  • cell cycle
  • nucleosome assembly
  • IRE1-mediated unfolded protein response
  • negative regulation of cell cycle
  • negative regulation of DNA replication
  • regulation of protein kinase activity
  • regulation of transcription, DNA-templated
  • regulation of signal transduction
  • negative regulation of cell growth
  • transcription, DNA-templated
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64061

52808

Ensembl

ENSG00000184205

ENSMUSG00000041096

UniProt

Q9H2G4

Q7TQI8

RefSeq (mRNA)

NM_022117

NM_029836
NM_145936
NM_001358369

RefSeq (protein)

NP_071400

NP_084112
NP_001345298

Location (UCSC)Chr X: 53.08 – 53.09 MbChr X: 151.12 – 151.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Testis-specific Y-encoded-like protein 2 is a protein that in humans is encoded by the TSPYL2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184205 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041096 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB (Apr 2001). "Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily". Genomics. 73 (2): 179–93. doi:10.1006/geno.2001.6505. PMID 11318608.
  6. ^ Chai Z, Sarcevic B, Mawson A, Toh BH (Sep 2001). "SET-related cell division autoantigen-1 (CDA1) arrests cell growth". J Biol Chem. 276 (36): 33665–74. doi:10.1074/jbc.M007681200. PMID 11395479.
  7. ^ "Entrez Gene: TSPYL2 TSPY-like 2".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wang GS, Hong CJ, Yen TY, et al. (2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron. 42 (1): 113–28. doi:10.1016/S0896-6273(04)00139-4. PMID 15066269.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Santama N, Ogg SC, Malekkou A, et al. (2006). "Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus". J. Biol. Chem. 280 (43): 36429–41. doi:10.1074/jbc.M501982200. PMID 16079131.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Radke JR, Donald RG, Eibs A, et al. (2006). "Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development". PLOS Pathog. 2 (10): e105. doi:10.1371/journal.ppat.0020105. PMC 1626100. PMID 17069459.
  • Tu Y, Wu W, Wu T, et al. (2007). "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways". J. Biol. Chem. 282 (16): 11722–31. doi:10.1074/jbc.M609623200. PMID 17317670.


  • v
  • t
  • e