TTC1

Protein-coding gene in humans
TTC1
Identifiers
AliasesTTC1, TPR1, tetratricopeptide repeat domain 1
External IDsOMIM: 601963; MGI: 1914077; HomoloGene: 2485; GeneCards: TTC1; OMA:TTC1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TTC1
Genomic location for TTC1
Band5q33.3Start160,009,113 bp[1]
End160,065,543 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TTC1
Genomic location for TTC1
Band11|11 B1.1Start43,620,339 bp[2]
End43,638,835 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • Achilles tendon

  • cingulate gyrus

  • left ventricle

  • anterior cingulate cortex

  • right frontal lobe

  • C1 segment

  • Brodmann area 9

  • prefrontal cortex

  • islet of Langerhans
Top expressed in
  • blastocyst

  • genital tubercle

  • tail of embryo

  • morula

  • spermatocyte

  • spermatid

  • secondary oocyte

  • muscle of thigh

  • zygote

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • unfolded protein binding
  • protein binding
Cellular component
  • peroxisomal membrane
  • cytosol
Biological process
  • protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7265

66827

Ensembl

ENSG00000113312

ENSMUSG00000041278

UniProt

Q99614

Q91Z38

RefSeq (mRNA)

NM_003314
NM_001282500

NM_133795

RefSeq (protein)

NP_001269429
NP_003305

NP_598556

Location (UCSC)Chr 5: 160.01 – 160.07 MbChr 11: 43.62 – 43.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetratricopeptide repeat protein 1 is a protein that in humans is encoded by the TTC1 gene.[5][6]


Interactions

TTC1 has been shown to interact with HSPA4.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113312 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041278 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
  6. ^ "Entrez Gene: TTC1 tetratricopeptide repeat domain 1".
  7. ^ Oh WK, Song Jaewhan (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1). Korea (South): 84–91. doi:10.1016/S1016-8478(23)13770-8. ISSN 1016-8478. PMID 14503850.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
  • Oh WK, Song J (2004). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1): 84–91. doi:10.1016/S1016-8478(23)13770-8. PMID 14503850.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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