TXNDC12

Protein-coding gene in the species Homo sapiens
TXNDC12
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1SEN, 2K8V

Identifiers
AliasesTXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDsOMIM: 609448; MGI: 1913323; HomoloGene: 41074; GeneCards: TXNDC12; OMA:TXNDC12 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TXNDC12
Genomic location for TXNDC12
Band1p32.3Start52,020,131 bp[1]
End52,055,191 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TXNDC12
Genomic location for TXNDC12
Band4|4 C7Start108,691,798 bp[2]
End108,719,324 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • rectum

  • gonad

  • stromal cell of endometrium

  • body of pancreas

  • islet of Langerhans

  • ventricular zone

  • placenta

  • gallbladder

  • olfactory zone of nasal mucosa
Top expressed in
  • medial ganglionic eminence

  • spermatocyte

  • endocardial cushion

  • dermis

  • calvaria

  • epithelium of lens

  • atrium

  • efferent ductule

  • atrioventricular valve

  • yolk sac
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity
  • protein-disulfide reductase (glutathione) activity
  • protein binding
Cellular component
  • endoplasmic reticulum lumen
  • endoplasmic reticulum
Biological process
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
  • cell redox homeostasis
  • cell differentiation
  • negative regulation of cell death
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51060

66073

Ensembl

ENSG00000117862

ENSMUSG00000028567

UniProt

O95881

Q9CQU0

RefSeq (mRNA)

NM_015913

NM_025334

RefSeq (protein)

NP_056997

NP_079610

Location (UCSC)Chr 1: 52.02 – 52.06 MbChr 4: 108.69 – 108.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.[5][6][7]

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors[8] (Liu et al., 2003).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117862 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028567 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ a b "Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)".
  8. ^ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Alanen HI, Williamson RA, Howard MJ, et al. (2003). "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member". J. Biol. Chem. 278 (31): 28912–20. doi:10.1074/jbc.M304598200. PMID 12761212.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Liu F, Rong YP, Zeng LC, et al. (2004). "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein". Gene. 315: 71–8. doi:10.1016/S0378-1119(03)00732-7. PMID 14557066.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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  • 1sen: Endoplasmic reticulum protein Rp19 O95881
    1sen: Endoplasmic reticulum protein Rp19 O95881
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TXNDC human genes


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