Tabtoxinine β-lactam
Names | |
---|---|
Systematic IUPAC name (2S)-2-Amino-4-[(3S)-3-hydroxy-2-oxoazetidin-3-yl]butanoic acid | |
Other names (αS,3S)-α-Amino-3-hydroxy-2-oxo-3-azetidinebutanoic acid; (−)-Tabtoxinine β-lactam | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChemSpider |
|
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C7H12N2O4 |
Molar mass | 188.183 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Tabtoxinine β-lactam is a monobactam antibiotic derived from tabtoxin. Unlike other β-lactam antibiotics, which inhibit penicillin-binding proteins, tabtoxinine β-lactam inhibits glutamine synthetase.[1]
References
- ^ Thomas, M. D.; Langston-Unkefer, P. J.; Uchytil, T. F.; Durbin, R. D. (1983). "Inhibition of Glutamine Synthetase from Pea by Tabtoxinine-β-lactam". Plant Physiology. 71 (4): 912–915. doi:10.1104/pp.71.4.912. PMC 1066143. PMID 16662928.
- v
- t
- e