UNC45A

Protein-coding gene in the species Homo sapiens
UNC45A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DBA

Identifiers
AliasesUNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A, OOHE
External IDsOMIM: 611219; MGI: 2142246; HomoloGene: 32423; GeneCards: UNC45A; OMA:UNC45A - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for UNC45A
Genomic location for UNC45A
Band15q26.1Start90,930,180 bp[1]
End90,954,093 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for UNC45A
Genomic location for UNC45A
Band7|7 D2Start79,975,040 bp[2]
End79,997,741 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • popliteal artery

  • tibial arteries

  • muscle layer of sigmoid colon

  • Descending thoracic aorta

  • ascending aorta

  • right hemisphere of cerebellum

  • body of uterus

  • skin of leg

  • gastric mucosa

  • stromal cell of endometrium
Top expressed in
  • external carotid artery

  • mucous cell of stomach

  • internal carotid artery

  • olfactory epithelium

  • lip

  • Rostral migratory stream

  • molar

  • neural layer of retina

  • tunica media of zone of aorta

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • Hsp90 protein binding
  • protein binding
  • cadherin binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • nucleus
  • Golgi apparatus
  • cytosol
  • nuclear speck
Biological process
  • multicellular organism development
  • cell differentiation
  • muscle organ development
  • chaperone-mediated protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55898

101869

Ensembl

ENSG00000140553

ENSMUSG00000030533

UniProt

Q9H3U1

Q99KD5

RefSeq (mRNA)
NM_001039675
NM_017979
NM_018671
NM_001323619
NM_001323620

NM_001323621

NM_133952

RefSeq (protein)

NP_001034764
NP_001310548
NP_001310549
NP_001310550
NP_061141

NP_598713

Location (UCSC)Chr 15: 90.93 – 90.95 MbChr 7: 79.98 – 80 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140553 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030533 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID 12356907. S2CID 44196958.
  6. ^ "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

  • Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC 2043524. PMID 17872978.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC 1430258. PMID 16478993.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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  • 2dba: The solution structure of the tetratrico peptide repeat of human Smooth muscle cell associated protein-1, isoform 2
    2dba: The solution structure of the tetratrico peptide repeat of human Smooth muscle cell associated protein-1, isoform 2


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