ZRANB2

Protein-coding gene in the species Homo sapiens

ZRANB2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1N0Z, 2K1P, 3G9Y

Identifiers

Aliases

ZRANB2, ZIS, ZIS1, ZIS2, ZNF265, zinc finger RANBP2-type containing 2

External IDs

OMIM: 604347; MGI: 1858211; HomoloGene: 135921; GeneCards: ZRANB2; OMA:ZRANB2 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p31.1	Start	71,063,291 bp^[1]
Band	1p31.1	End	71,081,289 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 H4	Start	157,239,797 bp^[2]
Band	3\|3 H4	End	157,254,047 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic epithelial cell

mucosa of ileum

Achilles tendon

cardiac muscle tissue of right atrium

corpus epididymis

caput epididymis

tibialis anterior muscle

anterior pituitary

tibia

myocardium of left ventricle

Top expressed in

genital tubercle

tail of embryo

medullary collecting duct

neural layer of retina

renal corpuscle

cerebellar cortex

atrioventricular valve

olfactory bulb

vestibular membrane of cochlear duct

primitive streak

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA-binding transcription factor activity protein binding metal ion binding RNA binding lipopolysaccharide binding
Cellular component	nucleus nucleoplasm
Biological process	mRNA processing RNA splicing regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9406


53861

Ensembl


ENSG00000132485


ENSMUSG00000028180

UniProt


O95218


Q9R020

RefSeq (mRNA)


NM_005455 NM_203350


NM_017381 NM_001355381 NM_001355386

RefSeq (protein)


NP_005446 NP_976225


NP_059077 NP_001342310 NP_001342315

Location (UCSC)

Chr 1: 71.06 – 71.08 Mb

Chr 3: 157.24 – 157.25 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.^[5]^[6]

Interactions

ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1^[7] and SNRP70.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028180 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (February 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene. 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.
^ "Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2".
^ ^a ^b Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adams DJ, van der Weyden L, Kovacic A, Lovicu FJ, Copeland NG, Gilbert DJ, Jenkins NA, Ioannou PA, Morris BJ (2000). "Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene". Cytogenet. Cell Genet. 88 (1–2): 68–73. doi:10.1159/000015487. PMID 10773668. S2CID 43262249.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.
Plambeck CA, Kwan AH, Adams DJ, Westman BJ, van der Weyden L, Medcalf RL, Morris BJ, Mackay JP (2003). "The structure of the zinc finger domain from human splicing factor ZNF265 fold". J. Biol. Chem. 278 (25): 22805–22811. doi:10.1074/jbc.M301896200. PMID 12657633.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Mangs AH, Speirs HJ, Goy C, Adams DJ, Markus MA, Morris BJ (2006). "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265". Nucleic Acids Res. 34 (17): 4976–4986. doi:10.1093/nar/gkl660. PMC 1635291. PMID 16982639.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.