MUC1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Protein_MUC1_PDB_2acm.png/250px-Protein_MUC1_PDB_2acm.png) |
Structure de la protéine MUC1. Basée sur le rendu PyMOL de PDB 2acm. |
Structures disponibles |
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PDB | Recherche UniProt humaine: PDBe RCSB |
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Identifiants PDB |
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1SM3, 2ACM |
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Identifiants |
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Aliases | MUC1, Mucin-1 |
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IDs externes | OMIM: 158340 HomoloGene: 136477 GeneCards: MUC1 |
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Position du gène (Homme) |
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![Chromosome 1 humain](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 humain[1] |
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| Locus | 1q22 | Début | 155,185,824 bp[1] |
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Fin | 155,192,916 bp[1] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - pylore
- pancreatic ductal cell
- nasal epithelium
- right uterine tube
- cardia
- olfactory zone of nasal mucosa
- lobe inférieur du poumon
- buccal mucosa cell
- muqueuse gastrique
- palpebral conjunctiva
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/PBB_GE_MUC1_207847_s_at_fs.png/250px-PBB_GE_MUC1_207847_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/PBB_GE_MUC1_213693_s_at_fs.png/250px-PBB_GE_MUC1_213693_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/PBB_GE_MUC1_211695_x_at_fs.png/250px-PBB_GE_MUC1_211695_x_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison protéique
- transcription coregulator activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- p53 binding
| Composant cellulaire | - région extracellulaire
- cytoplasme
- integral component of membrane
- noyau
- Golgi lumen
- integral component of plasma membrane
- apical plasma membrane
- membrane
- vésicule
- exosome
- milieu extracellulaire
- membrane plasmique
| Processus biologique | - positive regulation of histone H4 acetylation
- regulation of transcription from RNA polymerase II promoter in response to stress
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- negative regulation of cell adhesion mediated by integrin
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- positive regulation of transcription from RNA polymerase II promoter in response to stress
- O-glycan processing
- negative regulation of transcription by competitive promoter binding
- stimulatory C-type lectin receptor signaling pathway
- cytokine-mediated signaling pathway
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001018016 NM_001018017 NM_001018021 NM_001044390 NM_001044391
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NM_001044392 NM_001044393 NM_001204285 NM_001204286 NM_001204287 NM_001204288 NM_001204289 NM_001204290 NM_001204291 NM_001204292 NM_001204293 NM_001204294 NM_001204295 NM_001204296 NM_001204297 NM_002456 NM_182741 NM_001371720 |
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RefSeq (protéine) | NP_001018016 NP_001018017 NP_001037855 NP_001037856 NP_001037857
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NP_001037858 NP_001191214 NP_001191215 NP_001191216 NP_001191217 NP_001191218 NP_001191219 NP_001191220 NP_001191221 NP_001191222 NP_001191223 NP_001191224 NP_001191225 NP_001191226 NP_002447 NP_001358649 NP_001191217.1 NP_001191225.1 NP_001037856.1 |
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Localisation (UCSC) | Chr 1: 155.19 – 155.19 Mb | n/a |
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Publication PubMed | [2] | n/a |
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Wikidata |
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