ACBD3
ACBD3 | |||||||||||||||||||||||||
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Pengidentifikasi | |||||||||||||||||||||||||
Alias | ACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3 | ||||||||||||||||||||||||
ID eksternal | OMIM: 606809 MGI: 2181074 HomoloGene: 11227 GeneCards: ACBD3 | ||||||||||||||||||||||||
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Spesies | Manusia | Tikus | |||||||||||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Lokasi (UCSC) | n/a | Chr 1: 180.55 – 180.58 Mb | |||||||||||||||||||||||
Pencarian PubMed | [2] | [3] | |||||||||||||||||||||||
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Golgi resident protein GCP60 adalah protein yang pada manusia dikodekan oleh gen ACBD3.[4]
Fungsi
Badan Golgi memainkan peran kunci dalam pemilahan dan modifikasi protein yang diekspor dari retikulum endoplasma. ACBD3 berperan menjaga struktur Golgi dan berinteraksi dengan giantin, yang mempengaruhi pengangkutan protein.[5] Protein yang dikodekan oleh gen ini terlibat dalam pemeliharaan struktur dan fungsi Golgi melalui interaksinya dengan protein raksasa membran integral. Gen ini mungkin juga terlibat dalam regulasi hormonal pembentukan steroid.[4]
Interaksi
ACBD3 telah terbukti berinteraksi dengan GOLGB1.[6]
Referensi
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
- ^ "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
- ^ Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200
. PMID 11590181.
Pranala luar
- Lokasi genom ACBD3 manusia dan halaman rincian gen ACBD3 dalam UCSC Genome Browser.
Bacaan lanjutan
- Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200
. PMID 11590181.
- Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein". Mol. Endocrinol. 15 (12): 2211–28. doi:10.1210/me.15.12.2211. PMID 11731621.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. Parameter
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yang tidak diketahui akan diabaikan (bantuan) - Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. doi:10.1096/fj.02-1066fje. PMID 12692076. Parameter
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yang tidak diketahui akan diabaikan (bantuan) - Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148
. PMID 15231748.
- Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. doi:10.1074/jbc.M603276200
. PMID 16870622.
- Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. doi:10.1074/jbc.M705794200
. PMID 17711851.
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