ACER2

Pengidentifikasi

Alias

ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2

ID eksternal

OMIM: 613492 MGI: 1920932 HomoloGene: 14986 GeneCards: ACER2

Ontologi gen
Fungsi molekuler	• dihydroceramidase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides • hydrolase activity • N-acylsphingosine amidohydrolase activity • ceramidase activity • metal ion binding
Komponen seluler	• komponen integral membran • integral component of Golgi membrane • badan Golgi • membran • Golgi membrane
Proses biologis	• positive regulation of cell death • respons terhadap asam retinoat • ceramide metabolic process • metabolisme lipid • sphingosine biosynthetic process • sphingolipid biosynthetic process • negative regulation of cell-matrix adhesion • positive regulation of cell population proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of cell adhesion mediated by integrin • cellular response to DNA damage stimulus • regulation of autophagy • DNA damage response, signal transduction by p53 class mediator • regulation of apoptotic process • ceramide catabolic process • sphingolipid metabolic process
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


340485


230379

Ensembl


ENSG00000177076


ENSMUSG00000038007

UniProt


Q5QJU3


Q8VD53

RefSeq (mRNA)


NM_001010887


NM_001290541 NM_001290543 NM_139306 NM_028605

RefSeq (protein)


NP_001010887


NP_001277470 NP_001277472 NP_647467

Lokasi (UCSC)

n/a

Pencarian PubMed

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Alkaline ceramidase 2 juga dikenal sebagai ACER2 adalah enzim ceramidase yang pada manusia dikodekan oleh gen ACER2.^[3]

Fungsi

Jalur ACER2/sphingosine memainkan peran penting dalam mengatur pematangan subunit integrin β1 (ITGB1) dan adhesi sel yang dimediasi oleh integrin β1.^[4]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331 . PMID 18619555.
^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785 . PMID 18945876.

Pranala luar

Lokasi genom ACER2 manusia dan halaman rincian gen ACER2 dalam UCSC Genome Browser.

Bacaan lanjutan

Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842 . PMID 15498874.