Allopregnanolon
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Nama IUPAC 1-(3-Hidroksi-10,13-dimetil- 2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradekahidro- 1H-Siklopenta[a] fenantren-17-yl)etanon | |
Nama lain 3α,5α-Tetrahidroprogesteron | |
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3DMet | {{{3DMet}}} |
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Nomor RTECS | {{{value}}} |
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Rumus kimia | C21H34O2 |
Massa molar | 318,49 g/mol |
Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa). | |
Referensi | |
Allopregnanolon (bahasa Inggris: Allopregnanolone, 3α-hydroxy-5α-pregnan-20-one, 3α,5α-tetrahydroprogesterone, THP, ALLO) merupakan neurosteroid yang mengikat pencerap GABA. ALLO disintesis di dalam otak oleh neuron piramidal[1] dari progesteron dengan bantuan enzim 5alfa-reduktase tipe I dan 3alfa-hidroksisteroid dehidrogenase.[2]
Rujukan
- ^ (Inggris) "Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice". Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago; Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A. Diakses tanggal 2010-06-18.
- ^ (Inggris) "Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis". Department of Psychiatry, Psychiatric Institute, University of Illinois; Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. Diakses tanggal 2010-06-18.
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