KLF17

KLF17
Pengidentifikasi
AliasKLF17, ZNF393, Zfp393, Kruppel-like factor 17, Kruppel like factor 17, ZLF393
ID eksternalOMIM: 609602 MGI: 2181068 HomoloGene: 12621 GeneCards: KLF17
Ontologi gen
Fungsi molekuler• DNA binding
• GO:0001948, GO:0016582 Ikatan protein plasma
• metal ion binding
• nucleic acid binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
Komponen seluler• Inti sel
Proses biologis• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• GO:1901227 negative regulation of transcription by RNA polymerase II
Sumber:Amigo / QuickGO
Ortolog
SpesiesManusiaTikus
Entrez

128209

75753

Ensembl

ENSG00000171872

ENSMUSG00000048626

UniProt

Q5JT82

Q8CFA7

RefSeq (mRNA)

NM_173484

NM_029416

RefSeq (protein)

NP_775755

NP_083692

Lokasi (UCSC)n/an/a
Pencarian PubMed[1][2]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

Krueppel-like factor 17 adalah protein yang pada manusia disandi oleh gen KLF17.[3][4] KLF17 merupakan faktor transkripsi yang berperan sebagai penghambat langkah awal dalam metastasis kanker payudara.[5]

Referensi

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474–82. Apr 2006. doi:10.1016/j.ygeno.2005.12.011. PMID 16460907. 
  4. ^ "Entrez Gene: KLF17 Kruppel-like factor 17". 
  5. ^ Huang, Qihong; Zhang, Lin; Coukos, George; Katsaros, Dionyssios; Showe, Louise C.; Klein-Szanto, Andres J.; Gimotty, Phyllis A.; Li, Anping; Gumireddy, Kiranmai (2009-11). "KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer". Nature Cell Biology (dalam bahasa Inggris). 11 (11): 1297–1304. doi:10.1038/ncb1974. ISSN 1476-4679. PMC 2784164 alt=Dapat diakses gratis. PMID 19801974.  Periksa nilai tanggal di: |date= (bantuan)Pemeliharaan CS1: Format PMC (link)