HLA-E |
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Estruturas disponíveis |
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PDB | Pesquisa Human UniProt: PDBe RCSB |
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Lista de códigos id do PDB |
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3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG |
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Identificadores |
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Nomes alternativos | HLA-E, antígeno de histocompatibilidade HLA classe I, cadeia alfa E, antígeno MHC classe I E |
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IDs externos | OMIM: 143010 HomoloGene: 134018 GeneCards: HLA-E |
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Ontologia genética |
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Função molecular | • beta-2-microglobulin binding • MHC class I protein binding • signaling receptor binding • natural killer cell lectin-like receptor binding • peptide antigen binding • T cell receptor binding
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Componente celular | • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • membrane • MHC class Ib protein complex • Golgi membrane • membrana plasmática • cell surface • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • Exossoma • recycling endosome membrane
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Processo biológico | • antigen processing and presentation • adaptive immune response • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • CD8-positive, alpha-beta T cell activation • interferon-gamma-mediated signaling pathway • processo do sistema imunitário • antigen processing and presentation of peptide antigen via MHC class I • positive regulation of T cell mediated cytotoxicity • positive regulation of TRAIL production • positive regulation of interleukin-4 production • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • positive regulation of interleukin-13 production • type I interferon signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 resposta imunitária • regulation of natural killer cell mediated immunity • positive regulation of natural killer cell mediated immunity • regulation of immune response • positive regulation of tumor necrosis factor production • sistema imune inato • positive regulation of CD8-positive, alpha-beta T cell proliferation • antigen processing and presentation of endogenous peptide antigen via MHC class Ib
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Sources:Amigo / QuickGO |
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Ortólogos |
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Espécie | Humano | Rato |
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Entrez | | |
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Ensembl | ENSG00000204592 ENSG00000225201 ENSG00000236632 ENSG00000230254 ENSG00000206493
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ENSG00000233904 ENSG00000229252 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (proteína) | | |
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Localização (UCSC) | n/a | n/a |
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Pesquisa PubMed | [1] | n/a |
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Wikidata |
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