Asparagin-tRNK ligaza

Asparagin-tRNK ligaza
Identifikatori
EC broj 6.1.1.22
CAS broj 37211-76-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC articles
PubMed articles
NCBI Protein search

Asparagin-tRNK ligaza (EC 6.1.1.22, asparaginil-tRNK sintetaza, asparaginil-transfer ribonukleatna sintetaza, asparaginil transfer RNK sintetaza, asparaginil transfer ribonukleinsko kiselinska sintetaza, asparagil-transfer RNK sintetaza, asparaginska translaza) je enzim sa sistematskim imenom L-asparagin:tRNKAsn ligaza(formira AMP).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-asparagin + tRNKAsn {\displaystyle \rightleftharpoons } AMP + difosfat + L-asparaginil-tRNKAsn

Reference

  1. Davies, M.R. and Marshall, R.D. (1972). „Partial purification of L-asparginyl-tRNA synthetase from rabbit liver”. Biochem. Biophys. Res. Commun. 47: 1386-1395. PMID 5040239. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

  • MeSH Asparagine---tRNA+ligase
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TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6