Bombezin
Bombezin | |||
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Drugi nazivi | Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | ||
Identifikacija | |||
CAS registarski broj | 31362-50-2 | ||
PubChem[1][2] | 16133891 | ||
IUPHAR ligand | 616 | ||
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Svojstva | |||
Molekulska formula | C71H110N24O18S | ||
Molarna masa | 1619.85 | ||
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Infobox references |
Bombezin je peptid sa 14-aminokiselina[3], koji je originalno izolovan iz kože žabe. On ima dva poznata homologa kod sisara koji se nazivaju neuromedin B i peptid oslobađanja gastrina.
Bombezin stimuliše oslobađanje gastrina i G ćelija. On aktivira tri različita G protein spregnuta receptora, koji su poznati kao BBR1 2 & 3.[4] On takođe aktivira te receptore u mozgu. Zajedno sa holecistokininom, on je drugi najveći izvor negativnog povratnog signala koji zaustavlja traženje hrane.[5]
Bombezin je takođe marker tumora za rak malih ćelija pluća, gastričnog karcinoma, i neuroblastoma.[6]
Povezano
- Neuromedin B
- Neuromedin U
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT (February 2008). „Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states”. Current Opinion in Endocrinology, Diabetes, and Obesity 15 (1): 58–64. DOI:10.1097/MED.0b013e3282f3709b. PMC 2631407. PMID 18185064.
- ↑ Weber HC (February 2009). „Regulation and signaling of human bombezin receptors and their biological effects”. Current Opinion in Endocrinology, Diabetes, and Obesity 16 (1): 66–71. PMID 19115523.
- ↑ Yamada K, Wada E, Wada K (November 2000). „Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice”. Annals of Medicine 32 (8): 519–29. PMID 11127929.
- ↑ Ohlsson B, Fredäng N, Axelson J (December 1999). „The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines”. Scandinavian Journal of Gastroenterology 34 (12): 1224–9. PMID 10636070.
Spoljašnje veze
![]() | Portal Hemija |
- p
- r
- u
Drugi |
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Kinini | |
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Neuromedini | |
Drugi | Angiotenzin • Bombezin • Peptid srodan kalcitoninu • Karnozin • Kokainom i amfetaminom regulisani transkript • Peptid indukovanja delta sna • FMRF amid • Galanin • Galaninu sličan peptid • Peptid oslobađanja gastrina • Neuropeptid S • Neuropeptid Y • Neurofizini • Neurotenzin • Pankreatični polipeptid • Aktivirajući peptid hipofizne adenilat ciklaze • RVD-Hpα • VGF |