Dugolančana-masna-kiselna-KoA ligaza
| Dugolančana-masna-kiselna-KoA ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 6.2.1.3 | ||||||||
| CAS broj | 9013-18-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dugolančana-masna-kiselna-KoA ligaza (EC 6.2.1.3, acil-KoA sintetaza, masno kiselinska tiokinaza (dugi lanac), acil-aktivirajući enzim, palmitoil-KoA sintaza, lignoceroil-KoA sintaza, arahidonil-KoA sintetaza, acil koenzim A sintetaza, acil-KoA ligaza, palmitoil koenzim A sintetaza, tiokinaza, palmitoil-KoA ligaza, acil-koenzim A ligaza, masno kiselinska KoA ligaza, dugolančani masni acil koenzim A sintetaza, oleoil-KoA sintetaza, stearoil-KoA sintetaza, dugolančana masna acil-KoA sintetaza, dugolančana acil KoA sintetaza, masno kiselinska elongaza, LCFA sintetaza, pristanoil-KoA sintetaza, ACS3, dugolančana acil-KoA sintetaza I, dugolančana acil-KoA sintetaza II, masna acil-koenzim A sintetaza, dugolančana acil-koenzim A sintetaza, FAA1) je enzim sa sistematskim imenom dugolančana masna kiselina:KoA ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + dugolančana masna kiselina + KoA AMP + difosfat + acil-KoA
Ovaj enzim deluje na širok opseg dugolančanih masnih kiselina.
Reference
- ↑ Bakken, A.M. and Farstad, M. (1989). „Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets”. Biochem. J. 261: 71-76. PMID 2528345.
- ↑ Hosaka, K., Mishima, M., Tanaka, T., Kamiryo, T. and Numa, S. (1979). „Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies”. Eur. J. Biochem. 93: 197-203. PMID 108099.
- ↑ Nagamatsu, K., Soeda, S., Mori, M. and Kishimoto, Y. (1985). „Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme”. Biochim. Biophys. Acta 836: 80-88. PMID 3161545.
- ↑ Tanaka, T., Hosaka, K., Hoshimaru, M. and Numa, S. (1979). „Purification and properties of long-chain acyl-coenzyme-A synthetase from rat liver”. Eur. J. Biochem. 98: 165-172. PMID 467438.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Long-chain-fatty-acid---CoA+ligase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
