Gliceril-etar monooksigenaza

Gliceril-etar monooksigenaza
Identifikatori
EC broj 1.14.16.5
CAS broj 37256-82-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
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Gliceril-etar monooksigenaza (EC 1.14.16.5, gliceril-etarska monooksigenaza, enzim odvajanja gliceril-etra, gliceril etarska oksigenaza, glicerilna eteraza, O-alkilglicerolna monooksigenaza) je enzim sa sistematskim imenom 1-alkil-sn-glicerol,tetrahidrobiopterin:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju:

1-O-alkil-sn-glicerol + tetrahidrobiopterin + O2 ⇌ {\displaystyle \rightleftharpoons } 1-O-(1-hidroksialkil)-sn-glicerol + dihidrobiopterin + H2O

Ovaj enzim razlaže alkilglicerole. Za njegovo dejstvo je neophodno gvožđe nevezano za hem, redukovani glutation i fosfolipidi.

Reference

  1. ↑ Ishibashi, T. and Imai, Y. (1983). „Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes”. Eur. J. Biochem. 132: 23-27. PMID 6840084. 
  2. ↑ Pfleger, E.C., Piantadosi, C. and Snyder, F. (1967). „The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species”. Biochim. Biophys. Acta 144: 633-648. PMID 4383918. 
  3. ↑ Snyder, F., Malone, B. and Piantadosi, C. (1973). „Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity”. Biochim. Biophys. Acta 316: 259-265. PMID 4355017. 
  4. ↑ Soodsma, J.F., Piantadosi, C. and Snyder, F. (1972). „Partial characterization of the alkylglycerol cleavage enzyme system of rat liver”. J. Biol. Chem. 247: 3923-3929. PMID 4402391. 
  5. ↑ Tietz, A., Lindberg, M. and Kennedy, E.P. (1964). „A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers”. J. Biol. Chem. 239: 4081-4090. PMID 14247652. 
  6. ↑ Taguchi, H. and Armarego, W.L. (1998). „Glyceryl-ether monooxygenase [EC 1.14.16.5. A microsomal enzyme of ether lipid metabolism”]. Med. Res. Rev. 18: 43-89. PMID 9436181. 
  7. ↑ Watschinger, K., Keller, M.A., Hermetter, A., Golderer, G., Werner-Felmayer, G. and Werner, E.R. (2009). „Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence”. Biol. Chem. 390: 3-10. PMID 19007315. 
  8. ↑ Werner, E.R., Hermetter, A., Prast, H., Golderer, G. and Werner-Felmayer, G. (2007). „Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay”. J. Lipid Res. 48: 1422-1427. PMID 17303893. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

  • MeSH Alkylglycerol+monooxygenase
  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6