Karboksilestaraza

Karboksilestaraza
Identifikatori
EC broj 3.1.1.1
CAS broj 9016-18-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC articles
PubMed articles
NCBI Protein search

Karboksilestaraza (EC 3.1.1.1, ali-esteraza, B-esteraza, monobutiraza, kokainska esteraza, prokainska esteraza, metilbutiraza, vitamin A esteraza, butirilna esteraza, karboksiesteraza, karboksilatna esteraza, karboksilna esteraza, metilbutiratna esteraza, triacetinska esteraza, karboksil estarska hidrolaza, butiratna esteraza, metilbutiraza, alfa-karboksilesteraza, propionilna esteraza, nespecifična karboksilesteraza, esteraza D, esteraza B, esteraza A, serin esteraza, karboksilno kiselinska esteraza, kokainska esteraza) je enzim sa sistematskim imenom karboksilna-estar hidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

karboksilni estar + H2O ⇌ {\displaystyle \rightleftharpoons } alkohol + karboksilat

Ovaj enzim ima široku specifičnost.

Reference

  1. ↑ Augusteyn, R.C., de Jersey, J., Webb, E.C. and Zerner, B. (1969). „On the homology of the active-site peptides of liver carboxylesterases”. Biochim. Biophys. Acta 171: 128-137. PMID 4884138. 
  2. ↑ Barker, D.L. and Jencks, W.P. (1969). „Pig liver esterase. Physical properties”. Biochemistry 8: 3879-3889. PMID 4981346. 
  3. ↑ Bertram, J. and Krisch, K. (1969). „Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney”. Eur. J. Biochem. 11: 122-126. PMID 5353595. 
  4. ↑ Burch, J. (1954). „The purification and properties of horse liver esterase”. Biochem. J. 58: 415-426. PMID 13208632. 
  5. ↑ Horgan, D.J., Stoops, J.K., Webb, E.C. and Zerner, B. (1969). „Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase”. Biochemistry 8: 2000-2006. PMID 5785220. 
  6. ↑ Malhotra, O.P. and Philip, G. (1966). „Specificity of goat intestinal esterase”. Biochem. Z. 346: 386-402. 
  7. ↑ Mentlein, R., Schumann, M. and Heymann, E. (1984). „Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes”. Arch. Biochem. Biophys. 234: 612-621. PMID 6208846. 
  8. ↑ Runnegar, M.T.C., Scott, K., Webb, E.C. and Zerner, B. (1969). „Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase”. Biochemistry 8: 2013-2018. PMID 5785222. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

  • MeSH Carboxylesterase
  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6