Piruvatna karboksilaza
Piruvatna karboksilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 6.4.1.1 | ||||||||
CAS broj | 9014-19-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Piruvatna karboksilaza (EC 6.4.1.1, piruvinska karboksilaza) je enzim sa sistematskim imenom piruvat:ugljen-dioksid ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + piruvat + HCO3- ADP + fosfat + oksaloacetat
Ovaj biotinilni protein sadrži mangan (životinjska tkiva) ili cink (kvasac).
Reference
- ↑ McClure, W.R., Lardy, H.A. and Kneifel, H.P. (1971). „Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity”. J. Biol. Chem. 246: 3569-3578. PMID 5578910.
- ↑ Scrutton, M.C., Young, M.R. and Utter, M.F. (1970). „Pyruvate carboxylase from baker's yeast. The presence of bound zinc”. J. Biol. Chem. 245: 6220-6227. PMID 5484476.
- ↑ Seubert, W. and Remberger, U. (1961). „Renigung und Wirkungsweise der Pyruvatcarboxylase aus Pseudomonas citronellolis”. Biochem. Z. 334: 401-414. PMID 13750403.
- ↑ Utter, M.F. and Keech, D.B. (1963). „Pyruvate carboxylase. I. Nature of the reaction”. J. Biol. Chem. 238: 2603-2608. PMID 14063279.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Pyruvate+carboxylase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6