Proproteinska konvertaza
Proproteinske konvertaze su familija proteina koji aktiviraju druge proteine. Mnnogi proteini su prvobitno neaktivni nakon sintese, zato što sadrže lance aminokiselina koji blokiraju njihovu aktnost. Proproteinske konvertaze uklanjanju te lance i time aktiviraju proteine. Prototipna proproteinska konvertaza je furin.[1] Proproteinske konvertaze imaju medicnski značaj, zato što učestvuju u mnoštvu važnih bioloških procesa, kao što je na primer sinteza holesterola.[2] Inhibitori proproteinskih konvertaza blokiraju dejstvo enzima ove klase, te time sprečavaju aktivaciju ciljnih supstrata. Mnoge proproteinske konvertaze, a posebno furin i PACE4, učestvuju u patološkim procesima kao što su viralne infekcije, inflamacija, hiperholesterolemija, i kancer, te su potencijalni biološki ciljevi za lečenje bolesti.[3]
Reference
- ↑ Andrew W. Artenstein and Steven M. Opal (2011-12-29). „Proprotein Convertases in Health and Disease”. N Engl J Med 365: 2507–2518. DOI:10.1056/NEJMra1106700.
- ↑ New Drugs for Lipids Set Off Race, By Andrew Pollak, New York Times, November 5, 2012
- ↑ Daniel Bassi, (2012). „The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis”. Morgan & Claypool Publishers. DOI:10.4199/C00060ED1V01Y201206PAC001.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Povezano
- Keksin, enzim
- Furin, enzim
Spoljašnje veze
- Protein Activation and Cancer eBook series
- Neuropeptides eBook series Arhivirano 2020-06-07 na Wayback Machine-u
- MeSH Proprotein+Convertases
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