Sukcinat-semialdehid dehidrogenaza
| Sukcinat-semialdehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Dodekamer sukcinat-semialdehid dehidrogenaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.2.1.24 | ||||||||
| CAS broj | 9028-95-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sukcinat-semialdehid dehidrogenaza (EC 1.2.1.24, sukcinat semialdehidna dehidrogenaza (NAD+), sukcinska semialdehidna dehidrogenaza (NAD+), sukcinil semialdehidna dehidrogenaza (NAD+), sukcinat semialdehid:NAD+ oksidoreduktaza) je enzim sa sistematskim imenom sukcinat-semialdehid:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sukcinat semialdehid + NAD+ +H2O sukcinat + NADH + 2 H+
Ovaj enzim učestvuje u degradaciji glutamata i 4-aminobutirata. On je sličan sa EC 1.2.1.79, sukcinatnom-semialdehidnom dehidrogenazom (NADP+), i EC 1.2.1.16, sukcinatnom semialdehidno dehidrogenazom (NAD(P)+), ali je specifičan za NAD+.
Reference
- ↑ Albers, R.W. and Koval, G.J. (1961). „Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain”. Biochim. Biophys. Acta 52: 29-35. PMID 13860092.
- ↑ Ryzlak, M.T. and Pietruszko, R. (1988). „Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase”. Arch. Biochem. Biophys. 266: 386-396. PMID 3190233.
- ↑ Busch, K.B. and Fromm, H. (1999). „Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides”. Plant Physiol. 121: 589-597. PMID 10517851.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Succinate-semialdehyde+dehydrogenase+(NAD+)
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
