Tironamin
Tironamin | |||
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IUPAC ime |
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Identifikacija | |||
CAS registarski broj | 500-78-7 ![]() | ||
PubChem[1][2] | 3083601 | ||
ChemSpider[3] | 2340781 ![]() | ||
MeSH | thyronamine | ||
ChEMBL[4] | CHEMBL201896 ![]() | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C14H15NO2 | ||
Molarna masa | 229.27 g mol−1 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Tironamin se odnosi na molekul, i njegove derivate: familiju dekarboksilisanih i dejodiranih metabolita tiroidnih hormona tiroksina (T4) i 3,5,3'-trijodotironina (T3).
Tipovi
Ova grupa obuhvata:
- Tironamin (T0AM)
- 3-Jodotironamin (T1AM), trag amin prisutan u nervnom sistemu. On je potencijalni prirodni ligand za trag amin-asocirani receptor TAAR1 (TAR1), G protein spregnuti receptor lociran u ćelijskoj membrani[5]
- 3,5-Dijodotironamin (T2AM)
- 3,5,3'-Trijodotironamin (T3AM)
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Piehl S, Hoefig CS, Scanlan TS, Köhrle J (2011). „Thyronamines - Past, Present, and Future”. Endocrine Reviews 32 (1): 64–80. DOI:10.1210/er.2009-0040. PMID 20880963.
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