Trifunkcioni purinski biosintetički protein adenozin-3

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Fosforibozilglicinamid formiltransferaza‎‎, fosforibozilglicinamid sintetaza, fosforibozilaminoimidazol sintetaza

PDB prikaz baziran na 1rbm.

Dostupne strukture

1MEJ, 1MEN, 1MEO, 1NJS, 1RBM, 1RBQ, 1RBY, 1RBZ, 1RC0, 1RC1, 1ZLX, 1ZLY, 2QK4, 2V9Y

Identifikatori

Simboli

GART; AIRS; GARS; GARTF; PAIS; PGFT; PRGS

Vanjski ID

OMIM: 138440 MGI: 95654 HomoloGene: 637 GeneCards: GART Gene

EC broj

6.3.3.1, 6.3.4.13 2.1.2.2, 6.3.3.1, 6.3.4.13

Ontologija gena
Molekularna funkcija	• aktivnost fosforibozilamin-glicinske ligaze • aktivnost fosforibozilformilglicinamidinske ciklo-ligaze • aktivnost fosforibozilglicinamidne formiltransferaze • ATP vezivanje
Celularna komponenta	• citozol
Biološki proces	• purinski nukleobazni metabolički proces • 'de novo' IMP biosintetički proces • purinski nukleobazni biosintetički proces

Ortolozi

Vrsta

Čovek

Miš

Entrez

2618

14450

Ensembl

ENSG00000159131

ENSMUSG00000022962

UniProt

P22102

Q64737

RefSeq (mRNA)

NM_000819

NM_010256

RefSeq (protein)

NP_000810

NP_034386

Lokacija (UCSC)

Chr 21:
34.88 - 34.92 Mb

Chr 16:
91.62 - 91.65 Mb

PubMed pretraga

[1]

[2]

Trifunkcioni purinski biosintetički protein adenozin-3 je enzim koji je kod ljudi kodiran GART genom.^[1]

Ovaj protein je trofunkcionalni polipeptid. On deluje kao fosforibozilglicinamid formiltransferaza (EC 6.3.4.13), fosforibozilglicinamidna sintetaza (EC 6.3.3.1), fosforibozilaminoimidazolna sintetaza (EC 2.1.2.2), koji je neophodan za de novo purinsku biosintezu.

Reference

↑ Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (July 1991). „Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes”. EMBO J. 10 (7): 1629–34. PMC 452831. PMID 2050105.

Literatura

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Zhang Y, Desharnais J, Marsilje TH, et al. (2003). „Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.”. Biochemistry 42 (20): 6043–56. DOI:10.1021/bi034219c. PMID 12755606.
Brodsky G, Barnes T, Bleskan J, et al. (1997). „The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome.”. Hum. Mol. Genet. 6 (12): 2043–50. DOI:10.1093/hmg/6.12.2043. PMID 9328467.
Kan JL, Moran RG (1997). „Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene.”. Nucleic Acids Res. 25 (15): 3118–23. DOI:10.1093/nar/25.15.3118. PMC 146841. PMID 9224613.
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Zhang Y, Desharnais J, Greasley SE, et al. (2002). „Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.”. Biochemistry 41 (48): 14206–15. DOI:10.1021/bi020522m. PMID 12450384.
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Manieri W, Moore ME, Soellner MB, et al. (2007). „Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.”. Biochemistry 46 (1): 156–63. DOI:10.1021/bi0619270. PMID 17198385.
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Povezano

Fosforibozilglicinamid formiltransferaza

Spoljašnje veze

MeSH Phosphoribosylglycinamide+formyltransferase

PDB Galerija

1rbm: Struktura ljudskog GAR Tfaznog kompleksa sa poliglutamatnom 10-(trifluoroacetil)-5,10-dideazaacikličnom-5,6,7,8-tetrahidrofolnom kiselinom

2qk4: Ljudska glicinamidna ribonukleotidna sintetaza

1rbz: Struktura ljudskog GAR Tfaznog kompleksa sa poliglutamatnom 10-(trifluoroacetil)-5,10-dideazaacikličnom-5,6,7,8-tetrahidrofolnom kiselinom

1zlx: Apo struktura ljudske glicinamidne ribonukleotidne transformilaze

1meo: Ljudska glicinamidna ribonukleotidna transformilaza pri pH 4.2

1rc1: Struktura ljudskog GAR Tfaznog kompleksa sa poliglutamatnom 10-(trifluoroacetil)-5,10-dideazaacikličnom-5,6,7,8-tetrahidrofolnom kiselinom

1zly: Struktura ljudske glicinamidne ribonukleotidne transformilaze u kompleksu sa alfa,beta-N-(hidroksiacetil)-D-ribofuranozilaminom i 10-formil-5,8,dideazafolatom