Vestipitant
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(IUPAC) ime | |||
---|---|---|---|
(2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 334476-64-1 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 9832383 | ||
Hemijski podaci | |||
Formula | C23H21F10N3O | ||
Mol. masa | 545.416 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Vestipitant je razvio GlaksoSmitKlajn. Ovaj lek deluje kao selektivni antagonist za NK1 receptor. On je u razvoju kao potencijalni antiemetik i anksiolitik[3][4], i kao lek za tinitus.[5]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Reddy, GK; Gralla, RJ; Hesketh, PJ (2006). „Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis”. Supportive cancer therapy 3 (3): 140–2. DOI:10.3816/SCT.2006.n.011. PMID 18632487.
- ↑ Brocco, M; Dekeyne, A; Mannoury La Cour, C; Touzard, M; Girardon, S; Veiga, S; De Nanteuil, G; Dejong, TR i dr.. (2008). „Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: a comparison to other agents”. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 18 (10): 729–50. DOI:10.1016/j.euroneuro.2008.06.002. PMID 18657401.
- ↑ Clinical Trials NCT00394056 Vestipitant Or Vestipitant/Paroxetine Combination In Subjects With Tinnitus And Hearing Loss
Povezano
Spoljašnje veze
![]() | Portal Medicina |
![]() | Portal Hemija |
- p
- r
- u
- Aprepitant
- Kasopitant
- Ezlopitant
- Fosaprepitant
- Maropitant
- Vestipitant
Šablon:Neuropeptidni ligandi