Epimeraza i racemaza
Epimeraze i racemaze su izomeraze koje katalizuju inverziju stereohemije u biološkim molekulima.[1] Racemaze katalizuju stereohemijsku inverziju asimetričnog atoma ugljenika u supstratu sa samo jednim centrom asimetrije. Epimeraze katalizuju stereohemijsku inverziju konfiguracije asimetričnog ugljenika u supstratu koji ima više od jednog centra simetrije, i stoga interkonvertuju epimere.
Ljudske epimeraze obuhvataju metilmalonil-CoA epimerazu, koja učestvuje u metaboličkom razlaganju aminokiselina izoleucina, metionina i valina, i UDP-glukoza 4-epimeraza, koja se koristi u krajnjem koraku metabolizma galaktoze - katalizuje reverzibilnu konverziju UDP-galaktoze u UDP-glukozu.
Reference
- ^ Tanner, ME. (2002). „Understanding nature's strategies for enzyme-catalyzed racemization and epimerization”. Acc. Chem. Res. 35 (4): 237—246. PMID 11955052. doi:10.1021/ar000056y.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
- Entry+Term+Epimerases на US National Library of Medicine Medical Subject Headings (MeSH)
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Izomeraze: Epimeraze i racemaze (EC 5.1)
Aminokiselinske racemaze: Fenilalaninska racemaza (ATP-hidrolizujuće) • Serinska racemaza
Metilmalonil CoA epimeraza
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6