GNA12
| Guanin nukleotid-vezujući protein (G protein), alfa 12 | |||||||||||
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 PDB prikaz baziran na 1zca. | |||||||||||
| Dostupne strukture | |||||||||||
| 1zca | |||||||||||
| Identifikatori | |||||||||||
| Simboli | GNA12; RMP; MGC104623; MGC99644; NNX3; gep | ||||||||||
| Vanjski ID | OMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2768 | 14673 | |||||||||
| Ensembl | ENSG00000146535 | ENSMUSG00000000149 | |||||||||
| UniProt | Q03113 | Q2NKI3 | |||||||||
| RefSeq (mRNA) | NM_007353 | XM_001001104 | |||||||||
| RefSeq (protein) | NP_031379 | XP_001001104 | |||||||||
| Lokacija (UCSC) | Chr 7: 2.73 - 2.85 Mb | Chr 5: 141.01 - 141.08 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.[1][2][3]
Interakcije
Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,[4] ARHGEF12,[5][6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1[7] i TEC.[6]
Reference
- ^ Chan AM; Fleming TP; McGovern ES; Chedid M; Miki T; Stuart A. Aaronson (1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol. 13 (2): 762—8. PMC 358958
. PMID 8423800. - ^ Kumar RN, Shore SK, Dhanasekaran N (2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene. 25 (6): 899—906. PMID 16247467. doi:10.1038/sj.onc.1209132.
- ^ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”.
- ^ Yamaguchi, Yoshiaki; Katoh Hironori; et al. (2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. England. 12 (15): 1353—8. ISSN 0960-9822. PMID 12176367. doi:10.1016/S0960-9822(02)01034-5.
- ^ Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9.
- ^ а б Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 . PMID 12515866. doi:10.1073/pnas.0234057100.
- ^ Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. United States. 276 (49): 46088—93. ISSN 0021-9258. PMID 11598136. doi:10.1074/jbc.M108711200.
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Spoljašnje veze
- GNA12+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
