Gingipain R
| Gingipain R | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.37 | ||||||||
| CAS broj | 159745-71-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Gingipain R (EC 3.4.22.37, Arg-gingipain, gingipain-1, argingipain, Arg-gingivain-55 proteinaza, Arg-gingivain-70 proteinaza, Arg-gingivain-75 proteinaza, arginin-specifična cisteinska proteaza, arginin-specifična gingipain, arginin-specifični gingivain, RGP-1, RGP) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina i malih molekula, sa preferencijom za Arg u P1
Ovu endopeptidazu izlučuje bakterija Porphyromonas gingivalis.
Reference
- ^ Chen, Z., Potempa, J., Polanowski, A., Wikstrom, M. and Travis, J. (1992). „Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis”. J. Biol. Chem. 267: 18896—18901. PMID 1527017. CS1 одржавање: Вишеструка имена: списак аутора (веза)
- ^ Kirszbaum, L., Sotiropoulos, C., Jackson, C., Cleal, S., Slakeski, N. and Reynolds, E.C. (1995). „Complete nucleotide sequence of a gene prtR of Porphyromonas gingivalis W50 encoding a 132 kDa protein that contains an arginine-specific thiol endopeptidase domain and a haemagglutinin domain”. Biochem. Biophys. Res. Commun. 207: 424—431. PMID 7857299. CS1 одржавање: Вишеструка имена: списак аутора (веза)
- ^ Pavloff, N., Potempa, J., Pike, R.N., Prochazka, V., Kiefer, M.C., Travis, J. and Barr, P.J. (1995). „Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein”. J. Biol. Chem. 270: 1007—1010. PMID 7836351. CS1 одржавање: Вишеструка имена: списак аутора (веза)
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
- Gingipain+R на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
- EC1 Oksidoreduktaze /spisak
- EC2 Transferaze /spisak
- EC3 Hidrolaze /spisak
- EC4 Lijaze /spisak
- EC5 Izomeraze /spisak
- EC6 Ligaze /spisak
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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