Streptozotocin
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Klinički podaci | |
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Prodajno ime | Streptozocin [Usan:Inn], Streptozocine [INN-French], Streptozocinium [Latin], Streptozocinum [INN-Latin] |
Drugs.com | Monografija |
Način primene | Intravenozno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 5-15 minuta |
Izlučivanje | Renalno |
Identifikatori | |
CAS broj | 18883-66-4 ![]() |
ATC kod | L01AD04 (WHO) |
PubChem | CID 29327 |
DrugBank | DB00428 ![]() |
ChemSpider | 27273 ![]() |
ChEBI | CHEBI:9288 ![]() |
ChEMBL | CHEMBL450214 ![]() |
Hemijski podaci | |
Formula | C8H15N3O7 |
Molarna masa | 265,221 |
SMILES
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InChI
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Fizički podaci | |
Tačka topljenja | 115 °C (239 °F) |
Streptozotocin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 265,221 Da.[1][2][3][4][5][6][7]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 8 |
Broj donora vodonika | 5 |
Broj rotacionih veza | 3 |
Particioni koeficijent[8] (ALogP) | -2,3 |
Rastvorljivost[9] (logS, log(mol/L)) | -0,5 |
Polarna površina[10] (PSA, Å2) | 151,9 |
Reference
- ^ Brentjens R, Saltz L: Islet cell tumors of the pancreas: the medical oncologist's perspective. Surg Clin North Am. 2001 Jun;81(3):527-42. PMID 11459269
- ^ Wang Z, Gleichmann H: GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes. 1998 Jan;47(1):50-6. PMID 9421374
- ^ Schnedl WJ, Ferber S, Johnson JH, Newgard CB: STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 1994 Nov;43(11):1326-33. PMID 7926307
- ^ VAVRA JJ, DEBOER C, DIETZ A, HANKA LJ, SOKOLSKI WT: Streptozotocin, a new antibacterial antibiotic. Antibiot Annu. 1959-1960;7:230-5. PMID 13841501
- ^ Mansford KR, Opie L: Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet. 1968 Mar 30;1(7544):670-1. PMID 4170654
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Streptozotocin
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