Tromboksan-A sintaza

Tromboksan A sintaza 1 (trombocitna)
Identifikatori
Simboli TBXAS1; BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vanjski ID OMIM: 274180 MGI: 98497 HomoloGene: 55549 GeneCards: TBXAS1 Gene
EC broj 5.3.99.5
Ontologija gena
Molekularna funkcija aktivnost monooksigenaze
aktivnost tromboksan-A sintaze
vezivanje jona gvožđa
aktivnost nosača elektrona
Celularna komponenta membrana endoplazmičnog retikuluma
integralno sa membranom
Biološki proces proces prostaglandinske biosinteze
proces eikozanoidnog metabolizma
proces ksenobiotičkog metabolizma
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6916 21391
Ensembl ENSG00000059377 ENSMUSG00000029925
UniProt P24557 P36423
RefSeq (mRNA) NM_001061.4 NM_011539.3
RefSeq (protein) NP_001052.2 NP_035669.3
Lokacija (UCSC) Chr 7:
139.48 - 139.72 Mb
Chr 6:
38.88 - 39.08 Mb
PubMed pretraga [1] [2]

Tromboksan-A sintaza 1 (EC 5.3.99.5, trombocit, citohrom P450, familija 5, potfamilija A), takođe poznata kao TBXAS1, je enzim koji je kod ljudi kodiran TBXAS1 genom.[1][2][3]

Reference

  1. ^ „Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)”. 
  2. ^ Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479—1484. PMID 1714723. doi:10.1016/0006-291X(91)91060-P. 
  3. ^ Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene. 173 (2): 251—256. PMID 8964509. doi:10.1016/0378-1119(95)00881-0. 

Literatura

  • Shen RF, Tai HH (1998). „Thromboxanes: synthase and receptors”. J. Biomed. Sci. 5 (3): 153—172. PMID 9678486. doi:10.1007/BF02253465. 
  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). „Molecular genetics of the human cytochrome P450 monooxygenase superfamily”. Xenobiotica. 28 (12): 1129—1165. PMID 9890157. doi:10.1080/004982598238868. 
  • Wang LH, Kulmacz RJ (2003). „Thromboxane synthase: structure and function of protein and gene”. Prostaglandins Other Lipid Mediat. 68-69: 409—422. PMID 12432933. doi:10.1016/S0090-6980(02)00045-X. 
  • Itoh S; Yanagimoto T; Tagawa S; et al. (1992). „Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region”. Biochim. Biophys. Acta. 1130 (2): 133—8. PMID 1562592. 
  • Yokoyama C; Miyata A; Ihara H; et al. (1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479—1484. PMID 1714723. doi:10.1016/0006-291X(91)91060-P. 
  • Ohashi K; Ruan KH; Kulmacz RJ; et al. (1992). „Primary structure of human thromboxane synthase determined from the cDNA sequence”. J. Biol. Chem. 267 (2): 789—93. PMID 1730669. 
  • Jones DA, Fitzpatrick FA, Malcolm KC (1991). „Thromboxane A2 synthesis in human erythroleukemia cells”. Biochem. Biophys. Res. Commun. 180 (1): 8—14. PMID 1930241. doi:10.1016/S0006-291X(05)81247-1. 
  • Wang LH, Ohashi K, Wu KK (1991). „Isolation of partial complementary DNA encoding human thromboxane synthase”. Biochem. Biophys. Res. Commun. 177 (1): 286—291. PMID 2043115. doi:10.1016/0006-291X(91)91980-Q. 
  • Nüsing R, Schneider-Voss S, Ullrich V (1990). „Immunoaffinity purification of human thromboxane synthase”. Arch. Biochem. Biophys. 280 (2): 325—330. PMID 2195994. doi:10.1016/0003-9861(90)90337-X. 
  • Mestel F; Oetliker O; Beck E; et al. (1980). „Severe bleeding associated with defective thromboxane synthetase”. Lancet. 1 (8160): 157. PMID 6101498. doi:10.1016/S0140-6736(80)90642-X. 
  • Miyata A; Yokoyama C; Ihara H; et al. (1994). „Characterization of the human gene (TBXAS1) encoding thromboxane synthase”. Eur. J. Biochem. 224 (2): 273—279. PMID 7925341. doi:10.1111/j.1432-1033.1994.00273.x. 
  • Wang LH, Tazawa R, Lang AQ, Wu KK (1995). „Alternate splicing of human thromboxane synthase mRNA”. Arch. Biochem. Biophys. 315 (2): 273—278. PMID 7986068. doi:10.1006/abbi.1994.1500. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—174. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Lee KD, Baek SJ, Shen RF (1994). „Cloning and characterization of the human thromboxane synthase gene promoter”. Biochem. Biophys. Res. Commun. 201 (1): 379—387. PMID 8198598. doi:10.1006/bbrc.1994.1712. 
  • Chase MB; Baek SJ; Purtell DC; et al. (1993). „Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization”. Genomics. 16 (3): 771—773. PMID 8325653. doi:10.1006/geno.1993.1264. 
  • Ruan KH, Wang LH, Wu KK, Kulmacz RJ (1993). „Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum”. J. Biol. Chem. 268 (26): 19483—90. PMID 8366093. 
  • Tazawa R; Green ED; Ohashi K; et al. (1996). „Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter”. Arch. Biochem. Biophys. 334 (2): 349—356. PMID 8900410. doi:10.1006/abbi.1996.0464. 
  • Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene. 173 (2): 251—256. PMID 8964509. doi:10.1016/0378-1119(95)00881-0. 
  • Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—156. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
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Spoljašnje veze

  • Thromboxane-A+Synthase на US National Library of Medicine Medical Subject Headings (MeSH)
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Izomeraze: Intramolekulske oksidoreduktaze (EC 5.3)
5.3.1: Aldoze/Ketoze
Triozafosfatna izomeraza • Fosfopentozna izomeraza • Manoza fosfat izomeraza • Glukozna izomeraza
5.3.2: Keto/Enol5.3.3: C=C
Steroidna D-izomeraza • Izopentenil-difosfatna delta izomeraza • Vinilacetil-CoA D-izomeraza • Mukonolaktonsk D-izomeraza • Holestenolna delta-izomeraza (EBP) • Metilitakonatna D-izomeraza • Akonitatna delta-izomeraza • Enoilna CoA izomeraza • Prostaglandin-A1 delta izomeraza • 5-karboksimetil-2-hidroksimukonatna D-izomeraza • Izopiperitenonska D-izomeraza • L-dopahromna izomeraza • Izomeraza polienska masne kiseline
5.3.4: S-S
Protein disulfidna izomeraza (PDIA3)
5.3.99: Drugi
Prostaglandin-D2 sintaza/Prostaglandin-D sintaza • Prostaglandin-E sintaza • Prostaciklin sintaza • Tromboksan-A sintaza
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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