VUF-8430
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Nazivi | |
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Preferisani IUPAC naziv 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester | |
Identifikacija | |
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3D model (Jmol) |
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Abrevijacija | VUF-8430 |
ChemSpider |
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SMILES
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Svojstva | |
C4H11N5S | |
Molarna masa | 161,23 g·mol−1 |
log P | -1,367 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
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Reference infokutije | |
VUF-8430 je histaminski agonist[3] koji je selektivan za H4 tip receptora.[4]
Reference
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). „Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury”. Neuroimmunomodulation. 14 (6): 317—25. PMID 18401194. doi:10.1159/000125048.
- ^ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). „Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.”. Journal of Medical Chemistry. 49 (23): 6650—1. PMID 17154494. doi:10.1021/jm060880d.
Spoljašnje veze
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Histaminergici
VMAT |
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HDC | |
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HNMT | |
DAO | Inhibitori: Aminoguanidin |
Endogeni | Histamin; Prekursori: L-Histidin; Kofaktori: Vitamin B6 |
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