Verteporfin
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Klinički podaci | |
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Drugs.com | Monografija |
Način primene | Intravenozno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 5-6 h |
Identifikatori | |
CAS broj | 129497-78-5 ![]() |
ATC kod | S01LA01 (WHO) |
PubChem | CID 5362420 |
DrugBank | DB00460 ![]() |
ChemSpider | 4515032 ![]() |
ChEMBL | CHEMBL1200573 ![]() |
Hemijski podaci | |
Formula | C41H42N4O8 |
Molarna masa | 718,794 |
SMILES
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InChI
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Verteporfin je organsko jedinjenje, koje sadrži 41 atom ugljenika i ima molekulsku masu od 718,794 Da.[1][2][3][4]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 10 |
Broj donora vodonika | 3 |
Broj rotacionih veza | 12 |
Particioni koeficijent[5] (ALogP) | 7,8 |
Rastvorljivost[6] (logS, log(mol/L)) | -10,5 |
Polarna površina[7] (PSA, Å2) | 173,6 |
Reference
- ^ Chan WM, Lim TH, Pece A, Silva R, Yoshimura N: Verteporfin PDT for non-standard indications--a review of current literature. Graefes Arch Clin Exp Ophthalmol. 2010 May;248(5):613-26. Epub 2010 Feb 17. PMID 20162298
- ^ Nowak-Sliwinska P, Karocki A, Elas M, Pawlak A, Stochel G, Urbanska K: Verteporfin, photofrin II, and merocyanine 540 as PDT photosensitizers against melanoma cells. Biochem Biophys Res Commun. 2006 Oct 20;349(2):549-55. Epub 2006 Aug 22. PMID 16945338
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. уреди
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Verteporfin
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