40S ribozomal protein S3

Uygun yapılar

Ortolog araması: PDBe RCSB

PDB kimlik kodlarının listesi
1WH9, 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 4V5Z, 5FLX, 4D61, 4UJC

Tanımlayıcılar

Başka adlar

RPS3

Dış kimlikler

OMIM: 600454 MGI: 1350917 HomoloGene: 779 GeneCards: RPS3

Gen yerleşimi (İnsan)

Krom.	11. Kromozom (insan)^[1]

Bant	11q13.4	Başlangıç	75,399,515 bç^[1]
Bant	11q13.4	Bitiş	75,422,280 bç^[1]

RNA ekspresyonu deseni

Daha çok ekspresyon verisi başvurusu

Gen ontolojisi
Moleküler işlevi	• tubulin binding • DNA N-glycosylase activity • small ribosomal subunit rRNA binding • iron-sulfur cluster binding • transcription factor binding • oxidized purine DNA binding • Hsp70 protein binding • lyase activity • enzyme binding • mRNA binding • structural constituent of ribosome • damaged DNA binding • ubiquitin-like protein conjugating enzyme binding • GO:0001948, GO:0016582 protein bağlanması • DNA-(apurinic or apyrimidinic site) endonuclease activity • oxidized pyrimidine DNA binding • endodeoxyribonuclease activity • protein kinase binding • supercoiled DNA binding • DNA binding • Hsp90 protein binding • microtubule binding • protein kinase A binding • RNA binding • kinase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0032403 protein-containing complex binding • class I DNA-(apurinic or apyrimidinic site) endonuclease activity • class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity • oxidized purine nucleobase lesion DNA N-glycosylase activity
Hücresel bileşeni	• sitoplazma • Sitozol • Polizom • membrane • focal adhesion • ruffle membrane • mitokondri • Hücre iskeleti • hücre çekirdeği • ribozom • Çekirdekçik • extracellular exosome • Hücre zarı • İğ iplikleri • mitochondrial matrix • small ribosomal subunit • mitotic spindle • mitochondrial inner membrane • cytosolic small ribosomal subunit • Nükleoplazma • GO:0005578 Hücrelerarası madde • Endoplazmik retikulum • NF-kappaB complex • GO:0097483, GO:0097481 postsynaptic density • HnRNP • Sinaps
Biyolojik süreci	• Segregasyon • positive regulation of endodeoxyribonuclease activity • cellular response to DNA damage stimulus • positive regulation of microtubule polymerization • Hücre döngüsü • GO:0097285 apoptoz • negative regulation of translation • GO:0009373 regulation of transcription, DNA-templated • viral transcription • response to TNF agonist • positive regulation of apoptotic signaling pathway • GO:0001306 response to oxidative stress • transcription, DNA-templated • SRP-dependent cotranslational protein targeting to membrane • positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of DNA N-glycosylase activity • positive regulation of JUN kinase activity • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of DNA repair • GO:1900404 positive regulation of DNA repair • positive regulation of NIK/NF-kappaB signaling • Hücre bölünmesi • spindle assembly • negative regulation of protein ubiquitination • GO:1901313 positive regulation of gene expression • translational initiation • regulation of translation • cellular response to hydrogen peroxide • protein biyosentezi • positive regulation of base-excision repair • GO:0100026 DNA onarımı • regulation of apoptotic process • rRNA processing • cytoplasmic translation • positive regulation of protein-containing complex assembly • positive regulation of interleukin-2 production • positive regulation of activated T cell proliferation • positive regulation of T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • cellular response to tumor necrosis factor
Kaynaklar:Amigo / QuickGO

Ortologlar

Türler

İnsan

Fare

Entrez


6188


27050

Ensembl


ENSG00000149273


ENSMUSG00000030744

UniProt


P23396


P62908

RefSeq (mRNA)


NM_001260507 NM_001005 NM_001256802 NM_001260506


NM_012052

RefSeq (protein)


NP_000996 NP_001243731 NP_001247435 NP_001247436


NP_036182

Yerleşim (UCSC)

Krom. 11: 75.4 – 75.42 Mb

n/a

PubMed araması

^[2]

^[3]

Vikiveri

İnsan'ı Gör/Düzenle

Fare'yi Gör/Düzenle

40S ribozomal protein S3, insanların 11. kromozomunda yer alan RPS3 geni tarafından kodlanan bir proteindir.^[4]^[5]^[6]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149273 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM (Aug 1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8). ss. 3842-9. doi:10.1128/MCB.11.8.3842. PMC 361167 $2. PMID 1712897.
^ Polakiewicz RD, Munroe DJ, Sait SN, Tycowski KT, Nowak NJ, Shows TB, Housman DE, Page DC (Jul 1995). "Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5". Genomics. 25 (2). ss. 577-80. doi:10.1016/0888-7543(95)80063-R . PMID 7789996.
^ "Entrez Gene: RPS3 ribosomal protein S3". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

Ek okuma

Bommer UA, Lutsch G, Stahl J, Bielka H (1992). "Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes". Biochimie. 73 (7–8). ss. 1007-19. doi:10.1016/0300-9084(91)90142-N. PMID 1742346.
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12). ss. 933-47. doi:10.1139/o95-101. PMID 8722009.
Zhang XT, Tan YM, Tan YH (1990). "Isolation of a cDNA encoding human 40S ribosomal protein s3". Nucleic Acids Res. 18 (22). s. 6689. doi:10.1093/nar/18.22.6689. PMC 332635 $2. PMID 2129557.
Kim J, Chubatsu LS, Admon A, Stahl J, Fellous R, Linn S (1995). "Implication of mammalian ribosomal protein S3 in the processing of DNA damage". J. Biol. Chem. 270 (23). ss. 13620-9. doi:10.1074/jbc.270.23.13620 . PMID 7775413.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2). ss. 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Tycowski KT, Shu MD, Steitz JA (1993). "A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3". Genes Dev. 7 (7A). ss. 1176-90. doi:10.1101/gad.7.7a.1176 . PMID 8319909.
Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1). ss. 144-9. doi:10.1111/j.1432-1033.1996.0144u.x . PMID 8706699.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2). ss. 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5). ss. 509-23. doi:10.1101/gr.8.5.509 . PMID 9582194.
Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3). ss. 379-90. doi:10.1101/gr.214202. PMC 155282 $2. PMID 11875025.
Lee CH, Kim SH, Choi JI, Choi JY, Lee CE, Kim J (2002). "Electron paramagnetic resonance study reveals a putative iron-sulfur cluster in human rpS3 protein". Mol. Cells. 13 (1). ss. 154-6. PMID 11911468.
Lim Y, Lee SM, Kim M, Lee JY, Moon EP, Lee BJ, Kim J (2002). "Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron". Gene. 286 (2). ss. 291-7. doi:10.1016/S0378-1119(02)00502-4. PMID 11943484.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2). ss. 97-105. doi:10.1038/ncb1086. PMID 14743216.
Jang CY, Lee JY, Kim J (2004). "RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis". FEBS Lett. 560 (1–3). ss. 81-5. doi:10.1016/S0014-5793(04)00074-2 . PMID 14988002.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33). ss. 12130-5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101 . PMC 514446 $2. PMID 15302935.