ADRA1A |
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Ідентифікатори |
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Символи | ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR, adrenoceptor alpha 1A |
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Зовнішні ІД | OMIM: 104221 MGI: 104773 HomoloGene: 68078 GeneCards: ADRA1A |
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Реагує на сполуку |
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адреналін, methoxamine, норадреналін, оксиметазолін, Фенілефрин, діазепам, альфузозин, BMY-7378, каберголін, клозапін, Ципрогептадин, доксазозин, indoramin, ketanserin, lisuride, міансерин, NAN 190, Фентоламін, пірибедил, рисперидон, ritanserin, roxindole, Силодозин, spiperone, spiroxatrine, тамсулозин, теразозин, terguride, WB-4101, празозин, Ізоксуприн, адреналін, норадреналін, Ефедрин, methoxamine hydrochloride, dabuzalgron, dipivefrin hydrochloride, doxazosin mesylate, oxymetazoline hydrochloride, phenoxybenzamine hydrochloride, phenylephrine hydrochloride, prazosin hydrochloride, tamsulosin hydrochloride, midodrine hydrochloride, alfuzosin hydrochloride[1] |
Онтологія гена |
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Молекулярна функція | • signal transducer activity • adrenergic receptor activity • protein heterodimerization activity • G protein-coupled receptor activity • alpha1-adrenergic receptor activity • GO:0001948, GO:0016582 protein binding |
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Клітинна компонента | • T-tubule • ядерна мембрана • integral component of membrane • клітинне ядро • integral component of plasma membrane • мембрана • Z discdkac • клітинна мембрана • цитоплазма • caveola • dopaminergic synapse • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of presynaptic membrane |
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Біологічний процес | • positive regulation of cardiac muscle contraction • negative regulation of cell population proliferation • response to hormone • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • positive regulation of MAPK cascade • GO:0007243 intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • GO:0072468 сигнальна трансдукція • organ growth • cell-cell signaling • positive regulation of smooth muscle contraction • activation of phospholipase C activity • pilomotor reflex • regulation of vasoconstriction • positive regulation of heart rate • positive regulation of synaptic transmission, GABAergic • positive regulation of systemic arterial blood pressure • G protein-coupled receptor signaling pathway • cечовипускання • calcium ion transport into cytosol • positive regulation of action potential • positive regulation of the force of heart contraction by epinephrine-norepinephrine • GO:0097285 апоптоз • smooth muscle contraction • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • GO:0010260 старіння людини • regulation of cardiac muscle contraction • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of protein kinase C signaling • negative regulation of Rho protein signal transduction • regulation of muscle contraction • adult heart development • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • positive regulation of cytosolic calcium ion concentration • positive regulation of vasoconstriction • negative regulation of autophagy • positive regulation of cardiac muscle hypertrophy • positive regulation of non-membrane spanning protein tyrosine kinase activity • cell growth involved in cardiac muscle cell development • regulation of synaptic vesicle exocytosis • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • neuron-glial cell signaling |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PBB_GE_ADRA1A_211490_at_fs.png/250px-PBB_GE_ADRA1A_211490_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/49/PBB_GE_ADRA1A_211491_at_fs.png/250px-PBB_GE_ADRA1A_211491_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f3/PBB_GE_ADRA1A_211492_s_at_fs.png/250px-PBB_GE_ADRA1A_211492_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_000680 NM_033302 NM_033303 NM_033304 NM_001322502
| NM_001322503 NM_001322504 |
| | NM_001271759 NM_001271760 NM_001271761 NM_013461 |
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RefSeq (білок) | NP_000671 NP_001309431 NP_001309432 NP_001309433 NP_150645
| NP_150646 NP_150647 |
| | NP_001258688 NP_001258689 NP_001258690 NP_038489 |
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Локус (UCSC) | Хр. 8: 26.75 – 26.87 Mb | Хр. 14: 66.87 – 67.01 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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