MUC5AC |
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Наявні структури |
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PDB | Пошук для людей: PDBe RCSB | Список кодів PDB | 5AJN, 5AJP, 5AJO | | |
Ідентифікатори |
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Символи | MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming |
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Зовнішні ІД | OMIM: 158373 MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC |
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Онтологія гена |
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Молекулярна функція | • extracellular matrix structural constituent |
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Клітинна компонента | • цитоплазма • Golgi lumen • extracellular region • екзосома • міжклітинний простір • клітинна мембрана • mucus layer |
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Біологічний процес | • phosphatidylinositol-mediated signaling • O-glycan processing • stimulatory C-type lectin receptor signaling pathway |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | ENSG00000215182 ENSG00000283158 |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 11: 1.16 – 1.2 Mb | Хр. 7: 141.34 – 141.37 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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MUC5AC (англ. Mucin 5AC, oligomeric mucus/gel-forming) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 5 654 амінокислот, а молекулярна маса — 585 570[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MSVGRRKLAL | | LWALALALAC | | TRHTGHAQDG | | SSESSYKHHP | | ALSPIARGPS |
GVPLRGATVF | | PSLRTIPVVR | | ASNPAHNGRV | | CSTWGSFHYK | | TFDGDVFRFP |
GLCNYVFSEH | | CGAAYEDFNI | | QLRRSQESAA | | PTLSRVLMKV | | DGVVIQLTKG |
SVLVNGHPVL | | LPFSQSGVLI | | QQSSSYTKVE | | ARLGLVLMWN | | HDDSLLLELD |
TKYANKTCGL | | CGDFNGMPVV | | SELLSHNTKL | | TPMEFGNLQK | | MDDPTDQCQD |
PVPEPPRNCS | | TGFGICEELL | | HGQLFSGCVA | | LVDVGSYLEA | | CRQDLCFCED |
TDLLSCVCHT | | LAEYSRQCTH | | AGGLPQDWRG | | PDFCPQKCPN | | NMQYHECRSP |
CADTCSNQEH | | SRACEDHCVA | | GCFCPEGTVL | | DDIGQTGCVP | | VSKCACVYNG |
AAYAPGATYS | | TDCTNCTCSG | | GRWSCQEVPC | | PGTCSVLGGA | | HFSTFDGKQY |
TVHGDCSYVL | | TKPCDSSAFT | | VLAELRRCGL | | TDSETCLKSV | | TLSLDGAQTV |
VVIKASGEVF | | LNQIYTQLPI | | SAANVTIFRP | | STFFIIAQTS | | LGLQLNLQLV |
PTMQLFMQLA | | PKLRGQTCGL | | CGNFNSIQAD | | DFRTLSGVVE | | ATAAAFFNTF |
KTQAACPNIR | | NSFEDPCSLS | | VENEKYAQHW | | CSQLTDADGP | | FGRCHAAVKP |
GTYYSNCMFD | | TCNCERSEDC | | LCAALSSYVH | | ACAAKGVQLG | | GWRDGVCTKP |
MTTCPKSMTY | | HYHVSTCQPT | | CRSLSEGDIT | | CSVGFIPVDG | | CICPKGTFLD |
DTGKCVQASN | | CPCYHRGSMI | | PNGESVHDSG | | AICTCTHGKL | | SCIGGQAPAP |
VCAAPMVFFD | | CRNATPGDTG | | AGCQKSCHTL | | DMTCYSPQCV | | PGCVCPDGLV |
ADGEGGCITA | | EDCPCVHNEA | | SYRAGQTIRV | | GCNTCTCDSR | | MWRCTDDPCL |
ATCAVYGDGH | | YLTFDGQSYS | | FNGDCEYTLV | | QNHCGGKDST | | QDSFRVVTEN |
VPCGTTGTTC | | SKAIKIFLGG | | FELKLSHGKV | | EVIGTDESQE | | VPYTIRQMGI |
YLVVDTDIGL | | VLLWDKKTSI | | FINLSPEFKG | | RVCGLCGNFD | | DIAVNDFATR |
SRSVVGDVLE | | FGNSWKLSPS | | CPDALAPKDP | | CTANPFRKSW | | AQKQCSILHG |
PTFAACHAHV | | EPARYYEACV | | NDACACDSGG | | DCECFCTAVA | | AYAQACHEVG |
LCVSWRTPSI | | CPLFCDYYNP | | EGQCEWHYQP | | CGVPCLRTCR | | NPRGDCLRDV |
RGLEGCYPKC | | PPEAPIFDED | | KMQCVATCPT | | PPLPPRCHVH | | GKSYRPGAVV |
PSDKNCQSCL | | CTERGVECTY | | KAEACVCTYN | | GQRFHPGDVI | | YHTTDGTGGC |
ISARCGANGT | | IERRVYPCSP | | TTPVPPTTFS | | FSTPPLVVSS | | THTPSNGPSS |
AHTGPPSSAW | | PTTAGTSPRT | | RLPTASASLP | | PVCGEKCLWS | | PWMDVSRPGR |
GTDSGDFDTL | | ENLRAHGYRV | | CESPRSVECR | | AEDAPGVPLR | | ALGQRVQCSP |
DVGLTCRNRE | | QASGLCYNYQ | | IRVQCCTPLP | | CSTSSSPAQT | | TPPTTSKTTE |
TRASGSSAPS | | STPGTVSLST | | ARTTPAPGTA | | TSVKKTFSTP | | SPPPVPATST |
SSMSTTAPGT | | SVVSSKPTPT | | EPSTSSCLQE | | LCTWTEWIDG | | SYPAPGINGG |
DFDTFQNLRD | | EGYTFCESPR | | SVQCRAESFP | | NTPLADLGQD | | VICSHTEGLI |
CLNKNQLPPI | | CYNYEIRIQC | | CETVNVCRDI | | TRLPKTVATT | | RPTPHPTGAQ |
TQTTFTTHMP | | SASTEQPTAT | | SRGGPTATSV | | TQGTHTTLVT | | RNCHPRCTWT |
KWFDVDFPSP | | GPHGGDKETY | | NNIIRSGEKI | | CRRPEEITRL | | QCRAKSHPEV |
SIEHLGQVVQ | | CSREEGLVCR | | NQDQQGPFKM | | CLNYEVRVLC | | CETPRGCHMT |
STPGSTSSSP | | AQTTPSTTSK | | TTETQASGSS | | APSSTPGTVS | | LSTARTTPAP |
GTATSVKKTF | | STPSPPPVPA | | TSTSSMSTTA | | PGTSVVSSKP | | TPTEPSTSSC |
LQELCTWTEW | | IDGSYPAPGI | | NGGDFDTFQN | | LRDEGYTFCE | | SPRSVQCRAE |
SFPNTPLADL | | GQDVICSHTE | | GLICLNKNQL | | PPICYNYEIR | | IQCCETVNVC |
RDITRPPKTV | | ATTRPTPHPT | | GAQTQTTFTT | | HMPSASTEQP | | TATSRGGPTA |
TSVTQGTHTT | | PVTRNCHPRC | | TWTTWFDVDF | | PSPGPHGGDK | | ETYNNIIRSG |
EKICRRPEEI | | TRLQCRAKSH | | PEVSIEHLGQ | | VVQCSREEGL | | VCRNQDQQGP |
FKMCLNYEVR | | VLCCETPKGC | | PVTSTPVTAP | | STPSGRATSP | | TQSTSSWQKS |
RTTTLVTTST | | TSTPQTSTTY | | AHTTSTTSAP | | TARTTSAPTT | | RTTSASPAST |
TSGPGNTPSP | | VPTTSTISAP | | TTSITSAPTT | | STTSAPTSST | | TSGPGTTPSP |
VPTTSITSAP | | TTSTTSAPTT | | STTSARTSST | | TSATTTSRIS | | GPETTPSPVP |
TTSTTSATTT | | STTSAPTTST | | TSAPTSSTTS | | SPQTSTTSAP | | TTSTTSGPGT |
TPSPVPTTST | | TSAPTTRTTS | | APKSSTTSAA | | TTSTTSGPET | | TPRPVPTTST |
TSSPTTSTTS | | APTTSTTSAS | | TTSTTSGAGT | | TPSPVPTTST | | TSAPTTSTTS |
APISSTTSAT | | TTSTTSGPGT | | TPSPVPTTST | | TSAPTTSTTS | | GPGTTPSAVP |
TTSITSAPTT | | STNSAPISST | | TSATTTSRIS | | GPETTPSPVP | | TASTTSASTT |
STTSGPGTTP | | SPVPTTSTIS | | VPTTSTTSAS | | TTSTTSASTT | | STTSGPGTTP |
SPVPTTSTTS | | APTTSTTSAP | | TTSTISAPTT | | STTSATTTST | | TSAPTPRRTS |
APTTSTISAS | | TTSTTSATTT | | STTSATTTST | | ISAPTTSTTL | | SPTTSTTSTT |
ITSTTSAPIS | | STTSTPQTST | | TSAPTTSTTS | | GPGTTSSPVP | | TTSTTSAPTT |
STTSAPTTRT | | TSVPTSSTTS | | TATTSTTSGP | | GTTPSPVPTT | | STTSAPTTRT |
TSAPTTSTTS | | APTTSTTSAP | | TSSTTSATTT | | STISVPTTST | | TSVPGTTPSP |
VPTTSTISVP | | TTSTTSASTT | | STTSGPGTTP | | SPVPTTSTTS | | APTTSTTSAP |
TTSTISAPTT | | STPSAPTTST | | TLAPTTSTTS | | APTTSTTSTP | | TSSTTSSPQT |
STTSASTTSI | | TSGPGTTPSP | | VPTTSTTSAP | | TTSTTSAATT | | STISAPTTST |
TSAPTTSTTS | | ASTASKTSGL | | GTTPSPIPTT | | STTSPPTTST | | TSASTASKTS |
GPGTTPSPVP | | TTSTIFAPRT | | STTSASTTST | | TPGPGTTPSP | | VPTTSTASVS |
KTSTSHVSIS | | KTTHSQPVTR | | DCHLRCTWTK | | WFDIDFPSPG | | PHGGDKETYN |
NIIRSGEKIC | | RRPEEITRLQ | | CRAESHPEVS | | IEHLGQVVQC | | SREEGLVCRN |
QDQQGPFKMC | | LNYEVRVLCC | | ETPKGCPVTS | | TPVTAPSTPS | | GRATSPTQST |
SSWQKSRTTT | | LVTTSTTSTP | | QTSTTSAPTT | | STTSAPTTST | | TSAPTTSTTS |
TPQTSISSAP | | TSSTTSAPTS | | STISARTTSI | | ISAPTTSTTS | | SPTTSTTSAT |
TTSTTSAPTS | | STTSTPQTSK | | TSAATSSTTS | | GSGTTPSPVT | | TTSTASVSKT |
STSHVSVSKT | | THSQPVTRDC | | HPRCTWTKWF | | DVDFPSPGPH | | GGDKETYNNI |
IRSGEKICRR | | PEEITRLQCR | | AKSHPEVSIE | | HLGQVVQCSR | | EEGLVCRNQD |
QQGPFKMCLN | | YEVRVLCCET | | PKGCPVTSTS | | VTAPSTPSGR | | ATSPTQSTSS |
WQKSRTTTLV | | TSSITSTTQT | | STTSAPTTST | | TPASIPSTTS | | APTTSTTSAP |
TTSTTSAPTT | | STTSTPQTTT | | SSAPTSSTTS | | APTTSTISAP | | TTSTISAPTT |
STTSAPTAST | | TSAPTSTSSA | | PTTNTTSAPT | | TSTTSAPITS | | TISAPTTSTT |
STPQTSTISS | | PTTSTTSTPQ | | TSTTSSPTTS | | TTSAPTTSTT | | SAPTTSTTST |
PQTSISSAPT | | SSTTSAPTAS | | TISAPTTSTT | | SFHTTSTTSP | | PTSSTSSTPQ |
TSKTSAATSS | | TTSGSGTTPS | | PVPTTSTASV | | SKTSTSHVSV | | SKTTHSQPVT |
RDCHPRCTWT | | KWFDVDFPSP | | GPHGGDKETY | | NNIIRSGEKI | | CRRPEEITRL |
QCRAESHPEV | | SIEHLGQVVQ | | CSREEGLVCR | | NQDQQGPFKM | | CLNYEVRVLC |
CETPKGCPVT | | STPVTAPSTP | | SGRATSPTQS | | TSSWQKSRTT | | TLVTTSTTST |
PQTSTTSAPT | | TSTIPASTPS | | TTSAPTTSTT | | SAPTTSTTSA | | PTHRTTSGPT |
TSTTLAPTTS | | TTSAPTTSTN | | SAPTTSTISA | | STTSTISAPT | | TSTISSPTSS |
TTSTPQTSKT | | SAATSSTTSG | | SGTTPSPVPT | | TSTTSASTTS | | TTSAPTTSTT |
SGPGTTPSPV | | PSTSTTSAAT | | TSTTSAPTTR | | TTSAPTSSMT | | SGPGTTPSPV |
PTTSTTSAPT | | TSTTSGPGTT | | PSPVPTTSTT | | SAPITSTTSG | | PGSTPSPVPT |
TSTTSAPTTS | | TTSASTASTT | | SGPGTTPSPV | | PTTSTTSAPT | | TRTTSASTAS |
TTSGPGSTPS | | PVPTTSTTSA | | PTTRTTPAST | | ASTTSGPGTT | | PSPVPTTSTT |
SASTTSTISL | | PTTSTTSAPI | | TSMTSGPGTT | | PSPVPTTSTT | | SAPTTSTTSA |
STASTTSGPG | | TTPSPVPTTS | | TTSAPTTSTT | | SASTASTTSG | | PGTSLSPVPT |
TSTTSAPTTS | | TTSGPGTTPS | | PVPTTSTTSA | | PTTSTTSGPG | | TTPSPVPTTS |
TTPVSKTSTS | | HLSVSKTTHS | | QPVTSDCHPL | | CAWTKWFDVD | | FPSPGPHGGD |
KETYNNIIRS | | GEKICRRPEE | | ITRLQCRAES | | HPEVNIEHLG | | QVVQCSREEG |
LVCRNQDQQG | | PFKMCLNYEV | | RVLCCETPRG | | CPVTSVTPYG | | TSPTNALYPS |
LSTSMVSASV | | ASTSVASSSV | | ASSSVAYSTQ | | TCFCNVADRL | | YPAGSTIYRH |
RDLAGHCYYA | | LCSQDCQVVR | | GVDSDCPSTT | | LPPAPATSPS | | ISTSEPVTEL |
GCPNAVPPRK | | KGETWATPNC | | SEATCEGNNV | | ISLRPRTCPR | | VEKPTCANGY |
PAVKVADQDG | | CCHHYQCQCV | | CSGWGDPHYI | | TFDGTYYTFL | | DNCTYVLVQQ |
IVPVYGHFRV | | LVDNYFCGAE | | DGLSCPRSII | | LEYHQDRVVL | | TRKPVHGVMT |
NEIIFNNKVV | | SPGFRKNGIV | | VSRIGVKMYA | | TIPELGVQVM | | FSGLIFSVEV |
PFSKFANNTE | | GQCGTCTNDR | | KDECRTPRGT | | VVASCSEMSG | | LWNVSIPDQP |
ACHRPHPTPT | | TVGPTTVGST | | TVGPTTVGST | | TVGPTTPPAP | | CLPSPICQLI |
LSKVFEPCHT | | VIPPLLFYEG | | CVFDRCHMTD | | LDVVCSSLEL | | YAALCASHDI |
CIDWRGRTGH | | MCPFTCPADK | | VYQPCGPSNP | | SYCYGNDSAS | | LGALPEAGPI |
TEGCFCPEGM | | TLFSTSAQVC | | VPTGCPRCLG | | PHGEPVKVGH | | TVGMDCQECT |
CEAATWTLTC | | RPKLCPLPPA | | CPLPGFVPVP | | AAPQAGQCCP | | QYSCACNTSR |
CPAPVGCPEG | | ARAIPTYQEG | | ACCPVQNCSW | | TVCSINGTLY | | QPGAVVSSSL |
CETCRCELPG | | GPPSDAFVVS | | CETQICNTHC | | PVGFEYQEQS | | GQCCGTCVQV |
ACVTNTSKSP | | AHLFYPGETW | | SDAGNHCVTH | | QCEKHQDGLV | | VVTTKKACPP |
LSCSLDEARM | | SKDGCCRFCP | | PPPPPYQNQS | | TCAVYHRSLI | | IQQQGCSSSE |
PVRLAYCRGN | | CGDSSSMYSL | | EGNTVEHRCQ | | CCQELRTSLR | | NVTLHCTDGS |
SRAFSYTEVE | | ECGCMGRRCP | | APGDTQHSEE | | AEPEPSQEAE | | SGSWERGVPV |
SPMH |
Секретований назовні.
Література
- Escande F., Aubert J.-P., Porchet N., Buisine M.P. (2001). Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. Biochem. J. 358: 763—772. PMID 11535137 DOI:10.1042/0264-6021:3580763
- Li D., Gallup M., Fan N., Szymkowski D.E., Basbaum C.B. (1998). Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J. Biol. Chem. 273: 6812—6820. PMID 9506983 DOI:10.1074/jbc.273.12.6812
- Klomp L.W., Van Rens L., Strous G.J. (1995). Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. Biochem. J. 308: 831—838. PMID 8948439 DOI:10.1042/bj3080831
- Lidell M.E., Hansson G.C. (2006). Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. Biochem. J. 399: 121—129. PMID 16787389 DOI:10.1042/BJ20060443
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Perez-Vilar J., Randell S.H., Boucher R.C. (2004). C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology. 14: 325—337. PMID 14718370 DOI:10.1093/glycob/cwh041
Примітки
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:7515 (англ.) . Архів оригіналу за 13 серпня 2017. Процитовано 8 вересня 2017.
- ↑ UniProt, P98088 (англ.) . Архів оригіналу за 24 вересня 2017. Процитовано 8 вересня 2017.
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