白细胞介素-8
Interleukin 8 | |||||||||||||
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标识 | |||||||||||||
代号 | IL8; CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1 | ||||||||||||
扩展标识 | 遗传学:146930 同源基因:47937 ChEMBL: 2157 GeneCards: IL8 Gene | ||||||||||||
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RNA表达模式 | |||||||||||||
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更多表达数据 | |||||||||||||
直系同源体 | |||||||||||||
物种 | 人类 | 小鼠 | |||||||||||
Entrez | 3576 | n/a | |||||||||||
Ensembl | ENSG00000169429 | n/a | |||||||||||
UniProt | P10145 | n/a | |||||||||||
mRNA序列 | NM_000584 | n/a | |||||||||||
蛋白序列 | NP_000575 | n/a | |||||||||||
基因位置 | Chr 4: 74.61 – 74.61 Mb | n/a | |||||||||||
PubMed查询 | [1] | n/a | |||||||||||
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白细胞介素-8(英語:Interleukin-8,简称为白介素-8或IL-8,亦称为趋化因子CXCL8)是巨噬细胞和上皮细胞等分泌的细胞因子[1]。白细胞介素-8结合趨化因子受体白细胞介素-8受体α(IL8RA, 又叫CXCR1)和白细胞介素-8受体β(IL8RB, 又叫CXCR2)而对嗜中性粒细胞(neutrophils)有细胞趋化作用而实现其对炎症反应的调节[2][1]。 白细胞介素-8还有很强的促血管生成作用。白细胞介素-8在小支气管炎[3] 和囊性纤维化[4] 的发病中起重要作用。
参见
- 趋化因子
- CXCR1
- CXCR2
参考文献
- ^ 1.0 1.1 Baggiolini, M.; Walz, A.; Kunkel, S. L. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84: 1045-1049, 1989.
- ^ Ahuja SK, Ozcelik T, Milatovitch A, Francke U, Murphy PM. Molecular evolution of the human interleukin-8 receptor gene cluster. Nat Genet. 1992 Sep;2(1):31-6.
- ^ Emi, M. et al., Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene. J. Hum. Genet. 44: 169-172, 1999.
- ^ Srivastava, M. et al., Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc. Nat. Acad. Sci. 101: 7693-7698, 2004.
外部链接
- Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21. (页面存档备份,存于互联网档案馆)
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