ALDH1A2

已知的結構

直系同源搜索: PDBe RCSB

PDBID列表
4X2Q

識別號

别名

ALDH1A2；, RALDH(II), RALDH2, RALDH2-T, aldehyde dehydrogenase 1 family member A2

外部ID

OMIM：603687 MGI：107928 HomoloGene：68368 GeneCards：ALDH1A2

基因位置（人类）

染色体	15號染色體^[1]

基因座	15q21.3	起始	57,953,424 bp^[1]
基因座	15q21.3	终止	58,497,866 bp^[1]

基因位置（小鼠）

染色体	小鼠9号染色体^[2]

基因座	9 D\|9 39.85 cM	起始	71,123,071 bp^[2]
基因座	9 D\|9 39.85 cM	终止	71,203,525 bp^[2]

基因本體
分子功能	• oxidoreductase activity • aldehyde dehydrogenase (NAD+) activity • retinal binding • retinal dehydrogenase activity • 3-chloroallyl aldehyde dehydrogenase activity • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
細胞組分	• 細胞質 • 细胞质基质 • 细胞质的核周区域
生物學過程	• cellular response to retinoic acid • proximal/distal pattern formation • response to cytokine • 垂体的发生 • response to estradiol • 9-cis-retinoic acid biosynthetic process • neural crest cell development • cardiac muscle tissue development • lung development • 肾的发生 • retinol metabolic process • heart morphogenesis • hindbrain development • retinoic acid metabolic process • retinal metabolic process • embryonic camera-type eye development • retinoic acid biosynthetic process • response to vitamin A • face development • positive regulation of gene expression • retinoic acid receptor signaling pathway • blood vessel development • embryonic limb morphogenesis • ureter maturation • neural tube development • neuron differentiation • positive regulation of cell population proliferation • regulation of endothelial cell proliferation • positive regulation of apoptotic process • 胰腺发育 • determination of bilateral symmetry • vitamin A metabolic process • liver development • forebrain development • camera-type eye development • 代謝 • morphogenesis of embryonic epithelium • embryonic digestive tract development • embryonic forelimb morphogenesis • anterior/posterior pattern specification • negative regulation of cell population proliferation • midgut development • retinoic acid receptor signaling pathway involved in somitogenesis • protein homotetramerization
Sources:Amigo / QuickGO

直系同源

物種

人類

小鼠

Entrez


8854


19378

Ensembl


ENSG00000128918


ENSMUSG00000013584

UniProt


O94788


Q62148

mRNA序列


NM_170697 NM_001206897 NM_003888 NM_170696


NM_009022

蛋白序列


NP_001193826 NP_003879 NP_733797 NP_733798


NP_033048

基因位置（UCSC）

Chr 15: 57.95 – 58.5 Mb

Chr 9: 71.12 – 71.2 Mb

PubMed查找

^[3]

^[4]

維基數據

檢視/編輯人類

檢視/編輯小鼠

醛脱氢酶1家族成员A2（英語：Aldehyde dehydrogenase 1 family, member A2），简称为ALDH1A2，或称为视黄醛脱氢酶2（简写为RALDH2），是在人体内一种由ALDH1A2基因编码的酶。^[5]^[6]此蛋白为醛脱氢酶蛋白家族成员，是负责催化视黄酸到视黄醛的合成的酶。视黄酸是维生素A（即视黄醇）的活性衍生物，是一种旁分泌激素信号分子，主要作用于发育中的组织和成年组织中。^[7]对小鼠中类似基因的研究表明，这种酶和细胞色素CYP26A1同时确立局部胚胎组织中的视黄酸浓度，促进后部器官发育和防止脊柱裂。ALDH1A2基因已确认有三种可编码不同亚型蛋白的转录变异体。^[6]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3. Mol Cell Biol. Dec 1998, 18 (12): 6939–50. PMC 109277 . PMID 9819382.
^ ^6.0 ^6.1 Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2.
^ Duester G. Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell. September 2008, 134 (6): 921–31. PMC 2632951 . PMID 18805086. doi:10.1016/j.cell.2008.09.002.

拓展阅读

Human ALDH1A2 genome location and ALDH1A2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
Wang X, Penzes P, Napoli JL. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. J. Biol. Chem. 1996, 271 (27): 16288–93. PMID 8663198. doi:10.1074/jbc.271.27.16288.
Zhao D, McCaffery P, Ivins KJ, 等. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Eur. J. Biochem. 1996, 240 (1): 15–22. PMID 8797830. doi:10.1111/j.1432-1033.1996.0015h.x.
Niederreither K, Subbarayan V, Dollé P, Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat. Genet. 1999, 21 (4): 444–8. PMID 10192400. doi:10.1038/7788.
Niederreither K, Abu-Abed S, Schuhbaur B, 等. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat. Genet. 2002, 31 (1): 84–8. PMID 11953746. doi:10.1038/ng876.
Strausberg RL, Feingold EA, Grouse LH, 等. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, 等. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Anderson NL, Polanski M, Pieper R, 等. The human plasma proteome: a nonredundant list developed by combination of four separate sources（页面存档备份，存于互联网档案馆） (PDF). Mol. Cell. Proteomics. 2004, 3 (4): 311–26. PMID 14718574. doi:10.1074/mcp.M300127-MCP200.
Gerhard DS, Wagner L, Feingold EA, 等. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Deak KL, Dickerson ME, Linney E, 等. Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Res. Part a Clin. Mol. Teratol. 2006, 73 (11): 868–75. PMID 16237707. doi:10.1002/bdra.20183.
Ribes V, Wang Z, Dollé P, Niederreither K. Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development. 2006, 133 (2): 351–61. PMID 16368932. doi:10.1242/dev.02204.