RBM15

RNA binding motif protein 15
RNA结合基序蛋白15
标识
代号 RBM15; OTT; OTT1; SPEN
扩展标识 遗传学：606077 鼠基因：2443205 同源基因：23383 GeneCards: RBM15 Gene
基因本体论描述
分子功能 · nucleotide binding

· protein binding

· poly(A) RNA binding
细胞成分 · nucleus

· nucleolus

· nuclear membrane
生物过程 · patterning of blood vessels

· positive regulation of transcription of Notch receptor target
· viral process
· negative regulation of myeloid cell differentiation
· negative regulation of transcription, DNA-templated
· spleen development
· ventricular septum morphogenesis

· placenta blood vessel development
Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 64783 229700
Ensembl ENSG00000162775 ENSMUSG00000048109
UniProt Q96T37 A0PJG5
mRNA序列 NM_001201545 NM_001045807
蛋白序列 NP_001188474 NP_001039272
基因位置 Chr 1:
110.88 – 110.89 Mb		 Chr 3:
107.33 – 107.33 Mb
PubMed查询 [1] [2]
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假定的的RNA结合蛋白15（Putative RNA-binding protein 15）是一种由人类基因 RBM15 编码的蛋白质[1][2][3] 。

参考文献

  1. ^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054. 
  2. ^ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. May 2001, 98 (10): 5776–9. PMC 33289 可免费查阅. PMID 11344311. doi:10.1073/pnas.101001498. 
  3. ^ Entrez Gene: RBM15 RNA binding motif protein 15. 

延伸阅读

  • Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 可免费查阅. PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link)
  • Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.  引文格式1维护：显式使用等标签 (link)
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins.. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446 可免费查阅. PMID 15302935. doi:10.1073/pnas.0404720101.  引文格式1维护：显式使用等标签 (link)
  • Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 可免费查阅. PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link)
  • Hsiao HH, Yang MY, Liu YC; et al. RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.. Am. J. Hematol. 2005, 79 (1): 43–5. PMID 15849773. doi:10.1002/ajh.20298.  引文格式1维护：显式使用等标签 (link)
  • Gregory SG, Barlow KF, McLay KE; et al. The DNA sequence and biological annotation of human chromosome 1.. Nature. 2006, 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.  引文格式1维护：显式使用等标签 (link)
  • Beausoleil SA, Villén J, Gerber SA; et al. A probability-based approach for high-throughput protein phosphorylation analysis and site localization.. Nat. Biotechnol. 2006, 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.  引文格式1维护：显式使用等标签 (link)
  • Lindtner S, Zolotukhin AS, Uranishi H; et al. RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.. J. Biol. Chem. 2007, 281 (48): 36915–28. PMID 17001072. doi:10.1074/jbc.M608745200.  引文格式1维护：显式使用等标签 (link)
  • Olsen JV, Blagoev B, Gnad F; et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.  引文格式1维护：显式使用等标签 (link)

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