1-Deoxy-D-xylulose 5-phosphate
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IUPAC name (2,3-dihydroxy-4-oxopentyl) dihydrogen phosphate | |
Other names DOXP | |
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MeSH | 1-deoxy-D-xylulose+5-phosphate |
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Properties | |
Chemical formula | C5H11O7P |
Molar mass | 214.11 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.[1]
Function
The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase.[2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.[2][3] In addition, the molecule is involved in making thiamine (Vitamin B1) and pyridoxol (Vitamin B6).[2]
The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.[1]
References
- ^ a b Bartee D, Freel Meyers CL (October 2018). "Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism". Accounts of Chemical Research. 51 (10): 2546–2555. doi:10.1021/acs.accounts.8b00321. PMC 6309272. PMID 30203647.
- ^ a b c Xiang S, Usunow G, Lange G, Busch M, Tong L (January 2007). "Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis". Journal of Biological Chemistry. 282 (4): 2676–2682. doi:10.1074/jbc.M610235200.
- ^ Bartee D, Freel Meyers CL (2018-07-24). "Targeting the Unique Mechanism of Bacterial 1-Deoxy- d -xylulose-5-phosphate Synthase". Biochemistry. 57 (29): 4349–4356. doi:10.1021/acs.biochem.8b00548. ISSN 0006-2960. PMC 6057799. PMID 29944345.
See also
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to HMG-CoA | |
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Ketone bodies | |
to DMAPP | |
Geranyl- | |
Carotenoid |
- Lanosterol
- 14-demethyllanosterol
- 4alpha-Methylzymosterol
- Zymosterone
- Zymosterol
- Zymosterol
- Zymostenol
- Lathosterol
- 7-Dehydrocholesterol
- Cholesterol
- Zymosterol
- Cholesta-7,24-dien-3-ol
- 7-Dehydrodesmosterol
- Desmosterol
- Cholesterol
to Steroid hormones
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- See here instead.
To Sitosterol |
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To Ergocalciferol |
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