Diiodotyrosine
Names | |
---|---|
Preferred IUPAC name (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChemSpider |
|
ECHA InfoCard | 100.005.539 |
IUPHAR/BPS |
|
MeSH | Diiodotyrosine |
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C9H9I2NO3 |
Molar mass | 432.982 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.
Function
DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).[1]
Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).
Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').
See also
References
- ^ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.
External links
- H03BX01 (WHO)
- v
- t
- e
Thyroid peroxidase inhibitors (thioamide) | |
---|---|
Block conversion of T4 to T3 | |
Sodium-iodide symporter inhibitor | |
Other |
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
This article about an organic halide is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e