Exosome component 2

Protein-coding gene in the species Homo sapiens

EXOSC2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2NN6

Identifiers

Aliases

EXOSC2, RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF

External IDs

OMIM: 602238; MGI: 2385133; HomoloGene: 6095; GeneCards: EXOSC2; OMA:EXOSC2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.12	Start	130,693,721 bp^[1]
Band	9q34.12	End	130,707,288 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 B	Start	31,560,727 bp^[2]
Band	2\|2 B	End	31,571,361 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

gonad

Achilles tendon

cerebellar hemisphere

left ovary

granulocyte

right hemisphere of cerebellum

right ovary

rectum

Top expressed in

embryo

molar

epiblast

blastocyst

yolk sac

embryo

morula

somite

ventricular zone

neural layer of retina

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	3'-5'-exoribonuclease activity exoribonuclease activity 7S RNA binding protein binding RNA binding
Cellular component	cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleus nucleoplasm nucleolus
Biological process	nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent rRNA catabolic process regulation of mRNA stability exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' CUT catabolic process positive regulation of cell growth exonucleolytic catabolism of deadenylated mRNA rRNA processing U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23404


227715

Ensembl


ENSG00000130713


ENSMUSG00000039356

UniProt


Q13868


Q8VBV3

RefSeq (mRNA)


NM_001282708 NM_001282709 NM_014285


NM_144886

RefSeq (protein)


NP_001269637 NP_001269638 NP_055100


NP_659135

Location (UCSC)

Chr 9: 130.69 – 130.71 Mb

Chr 2: 31.56 – 31.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.^[5]^[6]

Function

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.^[7]

Interactions

Exosome component 2 has been shown to interact with:

Exosome component 4,^[8] and
Exosome component 7.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130713 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039356 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EXOSC2 exosome component 2".
^ Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D (November 1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4): 457–66. doi:10.1016/S0092-8674(00)80432-8. PMID 9390555. S2CID 16035676.
^ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
^ ^a ^b Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.

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Groffen J, Heisterkamp N, Grosveld F, et al. (1982). "Isolation of human oncogene sequences (v-fes homolog) from a cosmid library". Science. 216 (4550): 1136–8. Bibcode:1982Sci...216.1136G. doi:10.1126/science.6281890. PMID 6281890.
Heisterkamp N, Groffen J, Stephenson JR (1983). "The human v-abl cellular homologue". J. Mol. Appl. Genet. 2 (1): 57–68. PMID 6302194.
Heisterkamp N, Stephenson JR, Groffen J, et al. (1984). "Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia". Nature. 306 (5940): 239–42. doi:10.1038/306239a0. PMID 6316147. S2CID 4258884.
Groffen J, Stephenson JR, Heisterkamp N, et al. (1984). "Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22". Cell. 36 (1): 93–9. doi:10.1016/0092-8674(84)90077-1. PMID 6319012. S2CID 9876892.
Chissoe SL, Bodenteich A, Wang YF, et al. (1995). "Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID 7665185.
Litz CE, McClure JS, Copenhaver CM, Brunning RD (1993). "Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia". Blood. 81 (6): 1567–72. doi:10.1182/blood.V81.6.1567.1567. PMID 8453102.
Mitchell P, Petfalski E, Tollervey D (1996). "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism". Genes Dev. 10 (4): 502–13. doi:10.1101/gad.10.4.502. PMID 8600032.
Mitchell P, Petfalski E, Shevchenko A, et al. (1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4): 457–66. doi:10.1016/S0092-8674(00)80432-8. PMID 9390555. S2CID 16035676.
Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.